The International Journal of Neuropsychopharmacology
September 1, 2026
Gabriella Gobbi
Abstract Background Lysergic acid diethylamide (LSD), a serotonergic psychedelic, has gained renewed interest for its potential anxiolytic effects in clinical trials. However, the neurobiological mechanisms underlying these effects remain poorly understood. Aims & Objectives The goal of this study is to understand the mechanism of action of LSD in animal models by using in vivo...
The International Journal of Neuropsychopharmacology
September 1, 2026
Jessica Mingardi, Stefano Spinosa, Noemi Nicosia et al.
Abstract Background Stress is a recognized risk factor for developmental and adult psychiatric disorders. Indeed, stressful events, particularly during the first phases of life, such as trauma, neglect or abuse, have been associated with increased psychiatric risk over the course of a lifetime, although with some sex-differences. Indeed, the biological sex shapes the stress response impacting...
Human Psychopharmacology: Clinical and Experimental
September 1, 2026
José Norberto Vásquez-Bonilla
OBJECTIVE: This review critically examines psilocybin, with particular emphasis on its pharmacokinetics and pharmacodynamics, including its serotonergic, neuroplastic, and anti-inflammatory mechanisms. It integrates historical context, preclinical and clinical evidence, and evaluates emerging therapeutic potential, safety, microdosing practices, and pharmacological interactions. METHODS: A...
Vértices
September 1, 2026
Leticia Almeida Castro, André Luiz Anjos Simões Júnior, Guilherme Gianizeli Corradi Simões et al.
Depression is a multifactorial mental disorder and a leading cause of global disability. A subset of patients does not respond to conventional antidepressants, characterizing treatment-resistant depression (TRD). This study aimed to investigate the therapeutic potential of psilocybin in TRD, focusing on its effects on neuroplasticity. An integrative literature review was conducted using PubMed,...
Annals of Neurosciences
August 31, 2026
Anurag Shrivastava, Bikesh Kumar Singh, Deepeshwar Singh
Background Heartfulness meditation (HM) is a heart-based meditation practice that features a unique yogic transmission that involves transfer of subtle energy from a certified, experienced meditator to an aspirant. Purpose This study was conducted on HM practice to assess the state (momentary changes during meditation result in temporary physiological and neurological shifts) and trait...
Brain and Behavior
August 30, 2026
Waqar Husain, Achraf Ammar, Urwa‐Tul Wusqa et al.
BACKGROUND: Religious and spiritual practices are among the most ancient and universal human behaviors, yet their neurobiological substrates remain incompletely characterized. Neurotheology-the scientific study of the relationship between spiritual experience and brain function-has produced growing evidence that such practices generate measurable, systematic, and neuroplastic changes in brain...
Neuroscience
August 30, 2026
Yang Wang, Sinem Cetinkaya Karaca, Mille Deckmann Rasmussen et al.
Classical psychedelics exert therapeutic effects on affective disorders, with serotonin 5-HT2A receptor activation thought to play a central role. The cellular mechanisms by which 5-HT2A signaling modulates neural circuits remain incompletely understood and may differ across mood-regulating brain regions. While psychedelic actions have been extensively studied in the medial prefrontal cortex,...
Neurotoxicology
August 30, 2026
Mola Mohammadi, Amin Saeedi, Ali Asghar Kheirkhah Vakilabad et al.
Ketamine presents a modern pharmacological paradox, acting as both a rapid-acting antidepressant and a drug of abuse with significant cognitive consequences. While its therapeutic potential is revolutionary, chronic exposure is increasingly associated with persistent and specific deficits in episodic and working memory. This narrative review moves beyond descriptive lists of ketamine's effects...
Nursing Edição Brasileira
August 27, 2026
Ana Júlia Costa Matias Gomes, Jéssica Camilo Ramos Rodrigues, Valber Pinheiro Padilha Filho
Os psicodélicos clássicos, como a psilocibina, o LSD e a DMT, têm despertado crescente interesse na psiquiatria moderna devido ao seu potencial terapêutico em transtornos resistentes ao tratamento. O mecanismo de ação primário dessas substâncias envolve o agonismo dos receptores de serotonina 5-HT2A, localizados principalmente no córtex pré-frontal. Esta revisão sistemática analisou como a...
Zenodo (CERN European Organization for Nuclear Research)
August 25, 2026
Ángel Carrasco, Juan Carlos Montañez
preprint
The Neuroperceptual Horizon Hypothesis proposes that the range of physical phenomena an organism can functionally incorporate into experience is constrained by receptors, transduction mechanisms, neural integration, learning, and technological tools. We extend this framework through the Quantum Neuroperceptual Horizon Hypothesis (QNPH), which examines how information originating in phenomena...