Zenodo (CERN European Organization for Nuclear Research)
August 21, 2026
Ivan Temprado-Ordiaz
preprint
3,4-Methylenedioxymethamphetamine (MDMA) has emerged as a promising therapeutic candidate for treatment-resistant neuropathic pain, offering a paradigm shift from transient palliative symptom masking toward disease-modifying neuroplastic reorganization. Preclinical and clinical evidence demonstrates that MDMA operates through an integrated, multi-tiered neurobiological cascade: presynaptic...
VCU Scholars Compass
August 21, 2026
Belle Buzzi
Tobacco use remains a leading cause of preventable morbidity and mortality worldwide, and current smoking cessation treatments are limited by low long-term efficacy. An interplay between positive and negative reinforcement drives high relapse rates. Psychedelic compounds, particularly psilocybin, have shown promising clinical outcomes for smoking cessation, yet the neurobiological and...
bioRxiv
August 20, 2026
Ilknur Kayikcioglu Bozkir, Ryan Lashin, Tiecheng Liu et al.
preprint
Psilocybin is a psychedelic which has been shown to induce neural plasticity through activation of intracellular serotonergic 5-HT2A receptors. It also produces brain-wide changes in structural and functional connectivity and holds promise as a therapeutic compound for treating anxiety and depression. Despite links between psilocybin-induced plasticity, the psychedelic experience, and reduction...
International Health Sciences Review
August 18, 2026
Samuel Cândido Freres, Marco Antonio Franco Cançado, Aline Ferreira Catrolio et al.
Treatment-resistant depression (TRD) represents one of the most complex forms of major depressive disorder, characterized by the persistence of clinically significant symptoms despite the performance of appropriate therapeutic interventions. This condition is associated with a worse prognosis, higher risk of recurrence, functional impairment, increased morbidity and mortality, and high...
European Journal of Pharmacology
August 18, 2026
Sumin Ban, Kyung Oh Jeon, Su Yeon Seo et al.
3-Fluorophenetrazine (3F-phenetrazine) is a novel amphetamine-like substance that is structurally similar to phenmetrazine and 3F-phenmetrazine. Despite the emergence of 3F-phenetrazine in recreational drug markets, its neuropharmacological profile and abuse liability remain poorly characterized. This study is the first to investigate the psychostimulant, rewarding, and reinforcing properties...
August 13, 2026
Giulio Tononi, Andrew M. Haun, Chen Song et al.
preprint
Everyone lives within a Perception Box (PB). What we see and hear—how we interpret it and what it means to us—depends on our brain and learning history. Recognizing that perception is subjective, and understanding why, are key steps to open our minds, counteract bias, and reduce suffering. This project seeks to establish a rigorous theoretical and empirical foundation for the science of the PB....
Zenodo (CERN European Organization for Nuclear Research)
August 12, 2026
Ivanna J. Joseph, Adam Schiavi, Dylan Bruschi
preprint
Background. Combining mindfulness training with transcranial direct current stimulation (tDCS) is feasible and generally well tolerated, but the existing literature has produced feasibility findings rather than mechanistic ones. No trial has contrasted a stimulation montage matched to the network a contemplative practice preferentially engages against a montage matched to a different practice's...
bioRxiv (Cold Spring Harbor Laboratory)
August 12, 2026
Orr Shahar, Alexander Botvinnik, Masha Chaykin et al.
preprint
Abstract N, N-dimethyltryptamine (DMT) and 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT) are structurally related tryptamine psychedelics with emerging therapeutic potential, yet their comparative acute pharmacology and longer-term neuroplastic effects remain incompletely defined. Here we show that DMT produces a bell-shaped dose–response curve in the mouse head-twitch response (HTR) assay,...
Frontiers in Psychiatry
August 11, 2026
Ngo Cheung
Quantum approaches to consciousness remain controversial, partly because any putative quantum state in the brain is expected to decohere rapidly in a warm, hydrated, and noisy environment. The present manuscript does not attempt to solve that biological problem directly. Instead, it treats microtubule-related interpretation as a deliberately hypothetical analogy and asks a narrower Level-A...
Frontiers in Human Neuroscience
August 11, 2026
Andreu Ballús Santacana
The low-frequency resonome of the human brain, understood as the structured hierarchy of infra-slow, delta, and theta electromagnetic field organization across approximately 0.1–8 Hz, is central to large-scale neural coordination, state transitions, sleep-wake dynamics, predictive regulation, and conscious access. Existing theories explain many aspects of these phenomena through neuronal...