Psychological and existential distress are common across the cancer trajectory and can impair quality of life, treatment adherence, and family functioning. Although psychosocial and pharmacological interventions provide meaningful support, their overall effects are often modest. This review examines the emerging role of psychedelic-assisted therapy (PAT) as a potential approach to better...
Psychedelic and substance-assisted therapies are attracting renewed scientific, clinical, and public interest as potential interventions for mental health disorders, particularly treatment-resistant depression, post-traumatic stress disorder, and substance use disorders. However, as the field moves from early efficacy trials toward clinical implementation, major questions remain regarding...
Revista CienciaUANLJuly 1, 2026Armando Ordaz‐hernández, M. Corona-Ramírez, Israel Jesús Orlando Guerrero
La psilocibina, presente en los “hongos mágicos”, y la 5-MeO-DMT, secretada por el sapo Incilius alvarius, fueron empleadas ancestralmente en rituales espirituales en México. Hoy, la ciencia las reconoce como terapias prometedoras contra depresión, ansiedad, estrés postraumático y adicciones resistentes a tratamientos convencionales. Actúan sobre receptores de serotonina y estimulan la...
Background. Ketamine provides rapid but short-lived antidepressant effects for treatment-resistant depression (TRD). To prolong this response, ketamine-assisted therapy (KAT) combines the drug's pharmacological effects with psychotherapy. Aim. This study aims to analyze scientific evidence regarding the synergistic interaction between ketamine's pharmacological effects and modern...
Preprints.orgJune 30, 2026Dirk Revenstorf, Joost (j.b.c.) Mertens, Martin Schipplick
preprint
The therapeutic use of ketamine and other psychoactive substances in psychiatry is attracting growing research interest, particularly in treatment-resistant depression and related conditions refractory to conventional care. Ketamine exerts direct pharmacological antidepressant effects through NMDA receptor antagonism and downstream neuroplastic mechanisms; its combination with structured...
NeuropsychiatrieJune 30, 2026Cielo A Estela-Fernandez, Reem Mohamed Yousif Elsheikh, Dal Bianco Beatrice et al.
Major depressive disorder (MDD) is a heterogeneous, debilitating disorder. A distinct subgroup within the MDD spectrum is identified to have treatment-resistant depression (TRD). There is an impetus to find alternative treatments for TRD to reduce disease burden and improve quality of life. Psychedelics have been used in the treatment of various psychiatric disorders since the 1950s, with...
The present research revisits the boundaries between quantum mechanics, biological systems and the cognitive structuring of beliefs, taking as a pillar the theoretical propositions of Amit Goswami's monistic idealism.The primary scope lies in articulating how the counterintuitive behaviors of subatomic physics provide a non-dualistic framework for phenomena previously restricted to spiritual...
This study examines the epistemological integration between Sufism and modern neuroscience in response to the persistent dichotomy between religious and scientific knowledge in contemporary Islamic thought. While previous studies have explored the psychological and functional dimensions of spirituality, few have systematically formulated an integrative epistemological framework connecting Sufi...
Journal of Psychiatric ResearchJune 23, 2026Júlio César Claudino Dos Santos, Sofia Januário Bolan, Guilherme Lodetti da Silva et al.
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition characterized by persistent deficits in social communication and interaction, restricted and repetitive patterns of behavior, and sensory processing alterations, frequently accompanied by anxiety, emotional dysregulation, and other psychiatric comorbidities. Despite advances in behavioral and pharmacological...
The human body possesses enzymatic machinery to both synthesize and rapidly degrade N,N-dimethyltryptamine (DMT). This coexistence raises a question: does DMT serve an endogenous function, or is it a metabolic byproduct with no physiological role? DMT is structurally almost identical to serotonin and binds to the same serotonin receptors. Serotonin is universally accepted as a neurotransmitter...