Artefactum
October 28, 2026
Pablo Henrique Ramos Silva, Julyana Padilha Sousa, Maria Gabrielly Ferreira Silva et al.
Mapear os mecanismos de neurotoxicidade associados a drogas ilícitas selecionadas, seus efeitos relatados sobre o sistema nervoso central e potenciais estratégias neuroprotetoras. Métodos: Revisão de escopo baseada em busca no PubMed, abrangendo publicações de 2020 a 2025, em português, inglês ou espanhol, com texto completo gratuito. O registro de seleção apresentado no trabalho identificou...
Artefactum
September 30, 2026
Pedro Paulo Dias Soares, Cláudio Henrique Ribeiro Reimer
Psychiatric disorders emerge from interactions among biological vulnerability, psychological processes, social context, and systems of meaning. The biopsychosocial model broadened clinical formulation beyond biomedical reductionism, while contemporary research has increasingly examined religion and spirituality as clinically relevant dimensions of mental health. This critical narrative review...
Artefactum
September 21, 2026
Davi Rodrigues de Oliveira, Maria Clara França de Lima Vieira
This article investigates the relationships between spirit, consciousness, being, and reality based on the philosophies of Georg Wilhelm Friedrich Hegel and Martin Heidegger. It starts from the Hegelian understanding of spirit as a movement of self-knowledge and as a process through which consciousness overcomes immediate forms of grasping reality towards the concept and absolute knowledge....
Artefactum
August 6, 2026
Laura Alves Dutra, Anne Karolyne Alves Martins, Marina Camarão Oliveira et al.
Introduction:Treatment-resistant depression (TRD) is defined by the persistence of depressive symptoms despite at least two adequate trials with different classes of antidepressants. Limitations of traditional monoaminergic drugs have driven the search for rapid-acting, innovative interventions such as ketamine and electroconvulsive therapy (ECT), which target neuroplasticity and the...