Depression during pregnancy is often overlooked and undertreated. Ketamine has been shown to exert prompt and sustained antidepressant effects in patients with depression, although concerns of potential neurotoxicity prohibit its use in pregnant women. Here, we aim to investigate the neurobehavioral effects of subanesthetic ketamine on pregnant mice and their offspring. We found that pregnant...
Depression in children is a concerning societal issue and can be associated with poor academic performance, school dropout, and poor overall quality of life. Additionally, child depression is often associated with parallel stress and depression in parents. This scenario highlights the urgent need for the development and implementation of accessible and scalable solutions that may cobenefit...
ABSTRACT In the 1950s–60s, serotonergic psychedelic drugs were studied as potential adjuvants to psychotherapy to treat addiction and alcoholism. However, starting in the 70s, preclinical and clinical studies on psychedelics stopped for decades because legislation controlled its recreational use, citing their hallucinogenic and psychotomimetic effects, as well as their abuse potential....
Após concluir esta atividade, os participantes deverão ser capazes de: Analisar os mecanismos farmacodinâmicos da cetamina, incluindo sua ação primária como antagonista do receptor NMDA e efeitos secundários sobre os receptores AMPA, sistemas opioides e vias de neuroplasticidade, a fim de otimizar a seleção do tratamento para pacientes com depressão resistente ao tratamento. Avaliar cenários...
After completing this activity, participants should be able to: Analyze the pharmacodynamic mechanisms of ketamine, including its primary action as an NMDA receptor antagonist and secondary effects on AMPA receptors, opioid systems, and neuroplasticity pathways, to optimize treatment selection for patients with treatment-resistant depression. Evaluate clinical scenarios to determine when...
Na het voltooien van deze activiteit moeten deelnemers in staat zijn om: De farmacodynamische mechanismen van ketamine te analyseren, inclusief de primaire werking als NMDA-receptorantagonist en secundaire effecten op AMPA-receptoren, opioïde systemen en neuroplasticiteitspathways, om de behandelkeuze voor patiënten met therapieresistente depressie te optimaliseren. Klinische scenario's te...
The influence of ovarian hormone fluctuations on neurochemistry, cognition, and psychological responses remains insufficiently examined in current psychedelic research and clinical protocols. Traditional practices and case studies underscore the importance of accounting for these factors in investigations of psychedelic effects. This opinion paper explores the critical intersections between...
Psychedelics have been studied since the 1950s as a potential treatment for alcohol use disorder (AUD), with over a dozen clinical trials of lysergic acid diethylamide (LSD), and several contemporary trials of psilocybin and ayahuasca for this indication. Herein, we characterize foundational studies from the 1950s to the present, with emphasis on key design factors that varied considerably...
Classic psychedelics and the gut microbiome interact bidirectionally through mechanisms involving 5-HT2A receptor signaling, neuroplasticity, and microbial metabolism. This viewpoint highlights how psychedelics may reshape microbiota and how microbes influence psychedelic efficacy, proposing microbiome-informed strategies─such as probiotics or dietary interventions─to personalize and enhance...
Promising results have emerged in the use of psychedelic drugs for treating depression. Despite multiple neural models attempting to elucidate the acute psychedelic experience, and an increased focus on potential mechanisms driving persistent change, the connections between the acute state and the enduring therapeutic outcomes remain elusive. This targeted review aims to bridge this gap by...