Frontiers in Psychiatry
July 30, 2026
Liangju Chen, Yonghua Chen, Ying Zhao et al.
Objectives: This article reviews the clinical status and treatment challenges of cancer-related depressive states, clarifies the mechanism of action of esketamine-a novel rapid-acting antidepressant-compares its efficacy with traditional drugs, evaluates safety and tolerability, and summarizes clinical evidence to support clinical practice and research. Methods: By searching databases such as...
Molecular Neurobiology
July 28, 2026
Candidate Biomarkers of Bipolar Disorder Progression: Implications for Ketamine and Psychedelic Interventions.
Psychopharmacology
July 28, 2026
Agnieszka Wawrzczak-Bargieła, Małgorzata Jelonek-Kozioł, Weronika Kumorek et al.
RATIONALE: Psilocybin (PSI) microdosing, defined as a repeated administration of sub-perceptual doses, has gained increasing attention as a potential therapeutic strategy for affective and anxiety disorders. However, some molecular mechanisms, particularly regarding epigenetic regulation in the medial prefrontal cortex (mPFC), remain poorly understood. OBJECTIVES: Therefore, the present study...
STUDIES IN HEALTH SCIENCES
July 27, 2026
Kleber Mirallia de Oliveira, Yohana Heloise Mirallia, A. C. Moreira et al.
Background: The practice of meditation and mindfulness techniques has garnered significant interest within the international scientific community due to its potential to induce functional and structural plasticity in the Central Nervous System (CNS). This advanced narrative review aims to analyze, refine, and systematize the neuroscientific foundations of meditation, correlating ultrastructural...
July 27, 2026
Asher Wenig, David B Newman
preprint
This project will use a PRISMA-guided systematic review and meta-analysis to examine whether age moderates anxiety and depression outcomes following psychoactive-assisted treatments. In this review, psychoactive-assisted treatments are defined as clinically structured treatments involving classic serotonergic psychedelics, MDMA, ketamine, or esketamine. The term is intentionally broader than...
Molecules
July 27, 2026
Hongyu Chen, Bowen Ke, Ruotian Jiang
Chronic pain is a complex disorder of central nervous system maladaptation, perpetuated not only by ascending nociceptive transmission but also by entrenched prior expectations. Conventional analgesics typically fail to reverse this cognitive rigidity and the ensuing pathological cycles. Classic psychedelics, however, are emerging as a promising avenue to help address this therapeutic impasse....
IBRO Neuroscience Reports
July 26, 2026
Jingwen Yang, Ting Huang, Meng Wang et al.
Background Deeper understanding of ketamine’s mechanism of action would contribute to the discovery of novel therapeutic targets with fast-onset actions. To gain insight on the mechanism underlying the antidepressant-like effects of ketamine, we focused on perineuronal nets (PNNs), an extracellular matrix structure that surrounds fast-spiking parvalbumin-positive interneurons and regulates...
Progress in Neuro-Psychopharmacology and Biological Psychiatry
July 24, 2026
Omer Baruch, Nadav Reiss, Doron Todder et al.
Post-traumatic stress disorder (PTSD) remains difficult to prevent after trauma, highlighting the need for early interventions that reduce the risk of chronic symptom development. This controlled study investigated the preventive potential of 3,4-methylenedioxymethamphetamine (MDMA) in a validated rat model of PTSD induced by predator scent stress (PSS). Adult male Sprague-Dawley rats (N = 175)...
Psychedelic Medicine
July 24, 2026
Matthew C. Company, Dylan J. Lifshitz, M. Farris Sawaya et al.
This narrative review traces how the scientific understanding of psychedelics has intersected with “reward processing” from before the Controlled Substances Act (CSA) era to the present, emphasizing how cultural and regulatory climates shaped what was viewed as an acceptable research question. Reward processing is treated as a family of partially overlapping phenomena: (1) reward-linked...
Molecular Brain
July 24, 2026
Rafael V Lima Da Cruz, Richardson N. Leão, Thiago C. Moulin
Abstract Adult dentate gyrus neurogenesis and cell proliferation are regulated by multiple physiological inputs, including experience-dependent signals that have been linked to the DNA glycosylase NEIL3. Whether NEIL3 also gates psychedelic-induced proliferation is unknown. Here we tested the effect of a single dose of 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT), a serotonergic agonist with...