Journal of Affective Disorders
August 10, 2026
Yves Martins Varela, Patrícia Cavalcanti-Ribeiro, Geovan Menezes de Sousa et al.
BACKGROUND: Ketamine is an effective rapid-acting treatment for treatment-resistant depression (TRD), producing antidepressant effects within hours of administration. Because it induces states of heightened neuroplasticity and psychological openness, psychotherapy may enhance its therapeutic effects. METHODS: This exploratory, nonrandomized, open-label clinical trial evaluated the adjunctive...
Current Psychology
June 1, 2026
Geovan Menezes de Sousa, Geissy Lainny de Lima-Araújo, Vagner Deuel de Oliveira Tavares et al.
Abstract Dispositional mindfulness, also known as trait mindfulness, refers to an individual dispositional tendency to attend the present moment experiences with openness, curiosity and awareness. It is often associated with well-being, particularly through its role with emotional regulation. Yet, it is not well understood how it may influence the expression of major depression symptoms. This...
medRxiv Preprint Server
May 31, 2026
Yves Martins Varela, Patrícia Cavalcanti-Ribeiro, Geovan Menezes de Sousa et al.
preprint
Background Ketamine has emerged as an effective rapid-acting treatment for treatment-resistant depression (TRD), producing significant antidepressant effects within hours of administration. Given ketamine’s capacity to induce states of heightened neuroplasticity and psychological openness, psychotherapy may represent a meaningful complement to its pharmacological effects — facilitating...
European Archives of Psychiatry and Clinical Neuroscience
March 28, 2026
Yves Martins Varela, Vagner Deuel O de Tavares, Luiza Macedo Delgado et al.
1 citation
The use of psychedelics in the treatment of psychopathologies has been expanding, highlighting Psychedelic-Assisted Psychotherapy (PAP) as a promising resource in mental health care. This systematic review investigates. This systematic review investigates whether and how cognitive-behavioral therapies are integrated with psychedelic substances—both classical and atypical—for the treatment of...