ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMescaline Analogs. V. p-Dialkylamino-β-phenethylamines and 9-(β-Aminoethyl)julolidineF. BENINGTON, R. D. MORIN, and L. C. CLARKCite this: J. Org. Chem. 1956, 21, 12, 1470–1472Publication Date (Print):December 1, 1956Publication History Published online1 May 2002Published inissue 1 December...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNotes - Mescaline Anaologs. VI. Mescaline HomologsF. Benington, R. C. Morin, and L. C. Clark, Jr.Cite this: J. Org. Chem. 1956, 21, 12, 1545–1546Publication Date (Print):December 1, 1956Publication History Published online21 February 2003Published inissue 1 December...
Mescaline produced an inhibitory state accompanied by a schizokenesis or dissociation of systems. This disharmony was also manifested in that the CS appeared to act in the same manner as the US. On this basis a neurodynamic theory of the mechanism of mescaline's actions is postulated: that under mescaline intoxication and in some mental illnesses, a dissociation of the second and first...
2 From the Research Division of the Central Islip State Hospital, Central Islip, New York. 3 From the Research Department of Manhattan State Hospital, Ward's Island, New York.
Mescaline, injected intravenously and intraperitoneally into dogs and cats and into the lateral ventricle of the brain of cats, produced acute autonomic effects followed by catatonia. These responses appeared to be altered or prevented by pretreatment with the ataraxic agents chlorpromazine, reserpine, and azacyclonol.
In a recent report concerning the reversibility by chlorpromazine of psychoses induced by means of mescaline andd-lysergic acid diethylamide (LSD-25), careful attention was given to the clinical and electroencephalographic changes.1Although the clinical changes of this reversal effect were immediate and striking, the conventional electroencephalographic changes were minimal, and it was...
Similarity between certain of the visual effects of mescaline and hypnagogic imagery has been independently noted by several investigators, one of the earliest of these being Weir Mitchell (1896). Our own research group first became interested in hypnagogic experiences when one of the writers, as subject, in seeking to communicate the character of his mescaline visions, likened them to images...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMESCALINE ANALOGS. IV. SUBSTITUTED 4,5,6-TRIMETHOXYINDOLESF. BENINGTON, R. D. MORIN, and LELAND C. CLARK JR.Cite this: J. Org. Chem. 1955, 20, 10, 1454–1457Publication Date (Print):October 1, 1955Publication History Published online1 May 2002Published inissue 1 October...
ADVERTISEMENT RETURN TO ISSUEPREVArticleMESCALINE ANALOGS. III. 2,4,6-TRIALKYL- AND 3,4-DIHYDROXY-5-METHOXY-β-PHENETHYLAMINESF. BENINGTON, R. D. MORIN, and LELAND C. CLARK JR.Cite this: J. Org. Chem. 1955, 20, 9, 1292–1296Publication Date (Print):September 1, 1955Publication History Published online1 May 2002Published inissue 1 September...
Background: Patients with ALS commonly exhibit pseudobulbar affect. Methods: The authors conducted a multicenter, randomized, double-blind, controlled, parallel, three-arm study to test a defined combination of dextromethorphan hydrobromide (DM) and quinidine sulfate (Q) (AVP-923) for the treatment of pseudobulbar affect in ALS. Q inhibits the rapid first-pass metabolism of DM. The effects of...