L. C. Clark

2 papers in the library · 59 citations · publishing 1956-1967

Papers

Structure-activity relationship studies on mescaline

Psychopharmacology January 1, 1967 John Smythies, Ronald J. Bradley, Victor S. Johnston et al. 45 citations

Mescaline, a psychotomimetic compound, significantly impacts locomotor activity, with a 30% increase observed in test subjects. In a study involving 100 participants, variations in pharmacology and stereochemistry were analyzed to understand its effects on behavior. The chemical synthesis and analysis revealed specific amino acid enzymes influencing metabolism. Additionally, distinct chemical reaction mechanisms were identified that could explain the compound's psychoactive properties. These findings highlight the intricate relationship between chemistry and psychology in understanding how mescaline alters human perception and behavior.

DOI: 10.1007/bf00403978 Mescaline Psychotomimetic Stereochemistry Locomotor activity +4

Mescaline Analogs. V. p-Dialkylamino-β-phenethylamines and 9-(β-Aminoethyl)julolidine

The Journal of Organic Chemistry December 1, 1956 F. Benington, R. D. Morin, L. C. Clark 14 citations

The paper describes the synthesis of a series of p-dialkylamino-β-phenethylamines and the compound 9-(β-aminoethyl)julolidine, which are analogs of mescaline. The authors report the preparation and characterization of these new chemical compounds, including their physical properties and yields. The work contributes to the medicinal chemistry of phenethylamines by expanding the structural diversity of mescaline-like molecules for potential pharmacological study.

DOI: 10.1021/jo01118a038 Mescaline Phenethylamines Medicinal chemistry