ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn Improved Synthesis of MescalineFred Benington and Richard D. MorinCite this: J. Am. Chem. Soc. 1951, 73, 3, 1353Publication Date (Print):March 1, 1951Publication History Published online1 May 2002Published inissue 1 March 1951https://pubs.acs.org/doi/10.1021/ja01147a505https://doi.org/10.1021/ja01147a505research-articleACS PublicationsRequest reuse...
Mescaline produces altered visual experiences of several types, whose vividness and degree of distortion is proportionate to the size of the dose. There are no sharp boundaries dividing abnormal sensibility, illusions, and hallucinations. Subjects who gave fewer responses of the type "I see it" when asked to imagine situations were more likely to hallucinate than other patients. Visual...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUltraviolet Absorption Spectra of Mescaline Sulfate and β-Phenylethylamine SulfateKurt Salomon and Albert F. BinaCite this: J. Am. Chem. Soc. 1946, 68, 11, 2403Publication Date (Print):November 1, 1946Publication History Published online1 May 2002Published inissue 1 November...
The various theories about the cause of hallucinations have been largely influenced by the material which the writers studied. Thus, Mayer-Gross formed his theory on observation of the fantom limb, Schroeder on observation of delirious states and Vogt on experience with electrical stimulation of the cerebral cortex. It lies in the nature of the subject that its study is based mainly on verbal...
The experimental reproduction of psychotic phenomena in the normal person is a subject which has attracted much attention in recent years from psychiatrists, and which has added remarkable and interesting facts to our clinical knowledge.
Progress in general medicine is brought about by clinical observation or carefully controlled experimental research. In psychiatry there is little opportunity for the latter approach. One of the few methods available at the present time is the use of intoxicating drugs. It was Kraepelin who first emphasized the importance of studying psychological changes produced by drugs. Following his lead...
Mescaline (3,4,5-trimethoxyphenethylamine) is a classic serotonergic psychedelic with a history of indigenous ceremonial use. There is renewed scientific interest in mescaline because of the potential psychiatric benefits of psychedelic-assisted therapy. Mescaline primarily exerts its psychoactive effects through serotonin-2A (5-HT 2A ) receptor agonism. There is a lack of controlled clinical...
Psilocybin shows therapeutic promise for several psychiatric disorders, but the acute perceptual and cognitive alterations produced by conventional doses (10-25 mg) require in-clinic supervision, which limits scalability. Whether the therapeutically relevant pharmacology of psilocybin can be separated from its hallucinogenic activity remains unresolved. To address this gap, we conducted a Phase...