Addiction
October 1, 1993
Henry David Abraham, Andrew M. Aldridge
140 citations
Abstract The continued endemic use of hallucinogenic drugs, and of LSD in particular, raises concern regarding their short and long term adverse consequences. The epidemiology of LSD abuse is reviewed suggesting an increase in LSD use among the young as the prevalence rates for other substances continues to fall. Evidence supports the association of LSD use with panic reactions, prolonged...
Synapse
February 1, 1993
Jennifer C. Garratt, Meenakshi Alreja, George K. Aghajanian
46 citations
Abstract The effects of LSD (d‐lysergic acid diethylamide) on rat facial motoneurons were compared to those of 5‐hydroxytryptamine (5‐HT) in brain slices by means of current clamp and single‐electrode voltage‐clamp recordings. As previously reported, 5‐HT, in part by decreasing a resting potassium conductance, produced a reversible depolarization (∼5 mV), an increase in input resistance, and an...
European Journal of Pharmacology
January 5, 1993
Lubo Zhang, Donald C. Dyer
7 citations
d-Lysergic acid diethylamide (LSD) produced dose-dependent contractions (EC50, 17.9 +/- 2.1 nM) on isolated ovine uterine artery of late pregnancy, which were competitively antagonized by ketanserin. The maximal contraction to LSD was 51% of the 5-HT response. LSD competitively antagonized (pA2 9.21) contractions produced to 5-hydroxytryptamine (5-HT). The results indicate that LSD is a partial...
Pharmacology, Biochemistry, and Behavior
December 1, 1992
P A Palumbo, Jerrold C Winter
26 citations
The stimulus effects of ibogaine were compared with those of yohimbine, an alpha 2-adrenoceptor antagonist, 2,5-dimethoxy-4-methylamphetamine (DOM), a 5-hydroxytryptamine2 (5-HT2) agonist, and lysergic acid diethylamide (LSD), a nonspecific 5-HT agonist. Rats were trained with either yohimbine (6 mg/kg), DOM (0.6 mg/kg), or LSD (0.1 mg/kg) vs. no treatment in a two-lever discrimination task....
Behavioural Pharmacology
February 1, 1992
J. Arnt
27 citations
The effects of sertindole, clozapine, Cis(Z)-flupentixol and haloperidol on the discriminative stimulus properties of d-amphetamine (dopamine DA stimulant), d-LSD (5-HT(2) agonist) and St 587 (alpha(1)-adrenoceptor agonist; 2-chloro-5-trifluoromethyl-phenylimino)-imidazolidine) have been studied. Sertindole, a putative antipsychotic compound with limbic selectivity, antagonized the effects of...
Journal of Medicinal Chemistry
1992
Robert Oberlender, Robert C. Pfaff, Michael P. Johnson et al.
17 citations
The (R)- and (S)-2-butylamides of d-lysergic acid were prepared and evaluated in behavioral and biochemical assays of 5-HT2 agonist activity. In rats trained to discriminate 0.08 mg/kg LSD tartrate from saline, both isomers completely substituted for the training stimulus. Similarly, both isomers were found to possess very high affinity in displacing [125I]-(R)-DOI...
Journal of Pharmacology and Experimental Therapeutics
September 1, 1991
Kevin D. Burris, M Breeding, Elaine Sanders‐bush
Activation of central serotonin 5HT2 receptors is believed to be the primary mechanism whereby lysergic acid diethylamide (LSD) and other hallucinogens induce psychoactive effects. This hypothesis is based on extensive radioligand binding and electrophysiological and behavioral studies in laboratory animals. However, the pharmacological profiles of 5HT2 and 5HT1C receptors are similar, making...
Journal of Neurology, Neurosurgery, and Psychiatry
August 1991
W M Behan, A M Bakheit, P O Behan et al.
A detailed pathological description of the muscle findings in a case of the neuroleptic malignant syndrome (NMS) following ingestion of lysergic acid diethylamide (LSD) is given, including the first ultrastructural analysis. Focal necrosis, oedema, and hypercontraction of fibres with glycogen and lipid depletion, were identified, all of which had resolved completely a year later. The findings...
Journal of Forensic Sciences
July 1, 1991
Ha Harris, T Kane
5 citations
Abstract The identification of lysergic acid diethylamide (LSD) has posed an analytical challenge for forensic science laboratories. In those cases in which a few doses are seized, only microgram quantities are available, often in forms which make isolation of the miniscule amount of LSD difficult. A method is described which yields small crystals of pure LSD in a form well-suited for analysis...
Perspectives in biology and medicine
June 1, 1991
Robert F. Ulrich, Bernard M. Patten
27 citations
THE RISE, DECLINE, AND FALL OF LSD ROBERT F. ULRICH and BERNARD M. PATTEN* The urge to transcend self-conscious selfhood is ... a principal appetite of the soul. When, for whatever reason, men and women fail to transcend themselves by means of worship, good worh and spiritual exercises, they are apt to resort to religion's chemical surrogates.—Aldous Huxley. [1] On April 16, 1943, a fascinating...