Stereoselective LSD-like activity in d-lysergic acid amides of R- and S-2-aminobutane
Journal of Medicinal Chemistry 1992 Robert Oberlender, Robert C. Pfaff, Michael P. Johnson et al. 17 citations
The (R)- and (S)-2-butylamides of d-lysergic acid were prepared and evaluated in behavioral and biochemical assays of 5-HT2 agonist activity. In rats trained to discriminate 0.08 mg/kg LSD tartrate from saline, both isomers completely substituted for the training stimulus. Similarly, both isomers were found to possess very high affinity in displacing [125I]-(R)-DOI...