Journal of Neurology, Neurosurgery, and Psychiatry
May 30, 2023
Devan Mair, Álvaro París, Safiya A Zaloum et al.
Background Nitrous oxide (N2O) is the second most common recreational drug used by 16- to 24-year-olds in the UK. Neurological symptoms can occur in some people that use N2O recreationally, but most information comes from small case series. Methods We describe 119 patients with N2O-myeloneuropathy seen at NHS teaching hospitals in three of the UK’s largest cities: London, Birmingham and...
Journal of Neurology, Neurosurgery, and Psychiatry
August 1, 2020
Mike Jay
6 citations
Mike Jay has written widely on the history of science and medicine, and particularly on the discovery of psychoactive drugs during the 18th and 19th centuries. His books on the subject include Emperors of Dreams: drugs in the nineteenth century (2000, revised edition 2011) and most recently High Society: mind-altering drugs in history and culture (2010), which accompanied the exhibition he...
Journal of Neurology, Neurosurgery, and Psychiatry
July 20, 2020
Robin Carhart-Harris
Robin Carhart-Harris moved to Imperial College London in 2008 after obtaining a PhD in Psychopharmacology from the University of Bristol and an MA in Psychoanalysis from Brunel University. At Imperial, he has designed and/or carried out brain imaging studies involving LSD, psilocybin, MDMA and DMT, plus a clinical trial of psilocybin for treatment-resistant depression, and an ongoing study...
Journal of Neurology, Neurosurgery, and Psychiatry
July 20, 2020
Matthew Butler, Mathieu Seynaeve, Timothy R. Nicholson et al.
Aims Functional neurological disorder (FND), formerly known as conversion disorder, causes a high burden of disability and distress, and is amongst the most commonly encountered conditions in neurology clinics and neuropsychiatry services, yet the therapeutic evidence base is limited. Research into psychedelics such as psilocybin and lysergic acid diethylamide (LSD) is currently being...
Journal of Neurology, Neurosurgery, and Psychiatry
August 6, 2013
R. Carhart-Harris
17 citations
After completing an undergraduate degree in Psychology in 2003, Robin studied psychoanalysis at Masters level, receiving his MA in 2004. In 2005, Robin began a four year PhD in Psychopharmacology at the University of Bristol. Working for Professor David Nutt and Dr Sue Wilson, Robin9s thesis focused on sleep and serotonin function in ecstasy users. Robin conducted a clinical study involving...
Journal of Neurology, Neurosurgery, and Psychiatry
January 2012
Jon Stone, Charles Warlow, Michael Sharpe
Functional weakness describes weakness which is inconsistent and incongruent with disease. It is also referred to as motor conversion disorder (DSM-IV), dissociative motor disorder (ICD-10) and 'psychogenic' paralysis. Studies of aetiology have focused on risk factors such as childhood adversity and life events; information on the nature and circumstance of symptom onset may shed light on the...
Journal of Neurology, Neurosurgery, and Psychiatry
March 28, 2011
Bjørnar den Hollander, M.L.J. Schouw, P.F.C. Groot et al.
27 citations
Various studies have shown that ecstasy (3,4-methylenedioxymethamphetamine) users display significant memory impairments, whereas their performance on other cognitive tests is generally normal. The hippocampus plays an essential role in short-term memory. There are, however, no structural human data on the effects of ecstasy on the hippocampus. The objective of this study was to investigate...
Journal of Neurology, Neurosurgery, and Psychiatry
October 22, 2010
G. Leschziner, Robin Howard, A.E. Williams et al.
3 citations
Sleep Paralysis is the persistence of REM atonia into the wakefulness. It is found in normal subjects, but is frequently seen in narcolepsy, in conjunction with hypnogogic hallucinations and cataplexy. We investigated whether sleep paralysis may be associated with sleep disorders other than narcolepsy. A retrospective review of all patients seen at St Thomas9 Sleep Disorders Centre over a...
Journal of Neurology, Neurosurgery, and Psychiatry
June 1, 2000
Euphrosyne Gouzoulis‐mayfrank
309 citations
The present data raise concern that use of ecstasy possibly in conjunction with cannabis may lead to cognitive decline in otherwise healthy young people. Although the nature of the emerging cognitive disturbance is not yet clear, an impairment of working memory might be the common denominator underlying or contributing to declines of performance in various tasks. The cognitive disturbance is...
Journal of Neurology, Neurosurgery, and Psychiatry
August 1991
W M Behan, A M Bakheit, P O Behan et al.
A detailed pathological description of the muscle findings in a case of the neuroleptic malignant syndrome (NMS) following ingestion of lysergic acid diethylamide (LSD) is given, including the first ultrastructural analysis. Focal necrosis, oedema, and hypercontraction of fibres with glycogen and lipid depletion, were identified, all of which had resolved completely a year later. The findings...