Cellular and Molecular Life Sciences
February 1, 1988
A. David Smith, David P. Geaney, Michael Schächter et al.
15 citations
Chronic treatment with phenothiazines and thioxanthenes has been found to enhance 5-HT-induced aggregation of human platelets. A method has been developed to study 5-HT2 receptor binding sites on platelets utilising [3H]-LSD and more recently 125I/LSD. Results are presented which suggest that the LSD binding site is indeed the 5-HT2 binding site and that the LSD binding characterises the...
Psychopharmacology
1988
M Titeler, R A Lyon, Richard A Glennon
Alterations in brain serotonergic function have been implicated in the mechanism of action of LSD, mescaline, and other similarly acting hallucinogenic drugs of abuse such as STP (2,5-dimethoxyphenylisopropylamine; DOM). In order to test the hypothesis that the mechanism of action of LSD and phenylisopropylamine hallucinogens is through stimulation of a specific brain serotonin receptor...
Neuroscience
1988
M.J. Kadan, P.R. Hartig
17 citations
The sensitive serotonergic radioligand 2-[125I]lysergic acid diethylamide was used to study the distribution and pharmacological binding properties of serotonin receptors in Aplysia californica. The high specific activity of this radioligand allowed us to develop a methodology for the investigation of receptor binding properties and receptor distribution in a single ganglion. [125I]Lysergic...
Journal of American History
March 1, 1987
Richard H. Immerman, Martin A. Lee, Bruce Shlain
40 citations
Journal Article Acid Dreams: The CIA, LSD, and the Sixties Rebellion. By Martin A. Lee and Bruce Shlain. (New York: Grove, 1985. xxiii + 343 pp. Cloth, $27.50; paper, $12.95.) Get access Richard H. Immerman Richard H. Immerman University of Hawaii Search for other works by this author on: Oxford Academic Google Scholar Journal of American History, Volume 73, Issue 4, March 1987, Pages...
Journal of Psychoactive Drugs
1987
John R. Neill
18 citations
(1987). “More Than Medical Significance”: LSD and American Psychiatry—1953 to 1966. Journal of Psychoactive Drugs: Vol. 19, No. 1, pp. 39-45.
Synapse
1987
Dean F. Wong, John R. Lever, Paul R. Hartig et al.
93 citations
Abstract N1‐([ 11 C]‐Methyl)‐2‐Br‐LSD ([ 11 C]‐MBL) has been developed as a positron emission tomography (PET) imaging agent for serotonin 5‐HT 2 receptors. In vitro receptor binding assays with nonradioactive MBL show high‐affinity binding to serotonin 5‐HT 2 receptors (K i = 0.5 nM), a secondary interaction of 8‐fold lower affinity with dopamine D 2 receptors, and low‐affinity interactions...
Psychopharmacology
1987
Kathryn A. Cunningham, J. B. Appel
84 citations
The neuropharmacological mechanisms underlying the behavioral effects of d-lysergic acid diethylamide (LSD) were assessed by comparing the discriminative stimulus properties of LSD with those of agonists and antagonists that act selectively at putative serotonin (5-hydroxytryptamine; 5-HT) receptor subtypes (5-HT1 and 5-HT2). Male Sprague-Dawley rats (N = 23) were trained to discriminate LSD...
Neuroscience Research
February 1986
J B Wei, C Y Chiang
Serotonergic and non-serotonergic neurons in the nucleus raphe magnus were identified by conduction velocities and spontaneous discharge rates. Eight of 13 serotonergic neurons were depressed by lysergic acid diethylamide (LSD) administration (40-50 micrograms/kg, i.p. or i.v.), while the others were non-responsive. Among 38 non-serotonergic neurons, 5 were depressed, 4 were excited and 29 were...
Pharmacology, Biochemistry, and Behavior
February 1986
S B Sparber, L P Dwoskin, M S Kleven
Brain perfusion experiments of conscious rats engaged in operant behavior and administered fluoxetine or LSD, with or without prior injection of 5-HTP, indicate there is probably more than one functional pool of 5-HT in the CNS. Furthermore, the fact that prior loading with the precursor is necessary before unmasking an effect of LSD suggests the LSD-sensitive pool is newly synthesized and...
Pharmacology, Biochemistry, and Behavior
February 1986
W R Martin, J W Sloan
Tryptamine produces pharmacologic effects in man and the chronic spinal dog which are similar to those produced by LSD, mescaline, psilocin, DMT, DOM and DOB. These effects include tachycardia, tachypnea, mydriasis, hyperreflexia, behavioral changes and in man, hallucinations. Chronic spinal dogs treated chronically with LSD became tolerant to its ability to produce mydriasis, tachycardia,...