Psychopharmacology
October 1995
David Fiorella, R A Rabin, Jerrold C Winter
In the context of animal studies of hallucinogens, an LSD-false positive is defined as a drug known to be devoid of hallucinogenic activity in humans but which nonetheless fully mimics LSD in animals. Quipazine, MK-212, lisuride, and yohimbine have all been reported to be LSD false positives. The present study was designed to determine whether these compounds also substitute for the stimulus...
Psychopharmacology
October 1995
David Fiorella, Scott Helsley, D S Lorrain et al.
The present study was designed to determine the effects of p-chlorophenylalanine (PCPA) and p-chloroamphetamine (PCA) administration on (1) the levels of serotonin (5-hydroxytryptamine, 5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in rat brain, (2) the sensitivity of LSD-trained rats to the stimulus effects of LSD, and (3) the maximal levels of 5-HT2A and 5-HT2C receptor mediated...
Psychopharmacology
August 1995
D Marona-Lewicka, D E Nichols
The influence of several alpha 2-adrenergic agents on the discriminative stimulus (DS) properties of lysergic acid diethylamide (LSD) was studied in rats trained to discriminate 0.08 mg/kg (186 nmol/kg) of LSD from saline in a two-lever operant paradigm. Only yohimbine fully mimicked LSD with an ED50 of 2.05 mg/kg (5.24 mumol/kg). Yohimbine's 5-HT1A agonist properties may be responsible for...
Australian & New Zealand Journal of Psychiatry
June 1, 1995
K. M. H. Perera, A. Ferraro, M. R. M. Pinto
11 citations
The case of a patient who developed catatonia one week following Lysergic Acid Diethylamide (LSD) ingestion is presented. The psychosis developed two days after the intake. The catatonic syndrome resolved dramatically following one treatment of electroconvulsive therapy (ECT). This is perhaps the first case report of catatonia following the use of LSD. The need for a diagnostic category of...
Pediatric Clinics of North America
April 1, 1995
R H Schwartz
LSD is making a comeback nationwide among Caucasian middle-class high school and college students. Compared to the mean values during the years 1985 to 1990, an approximately 25% increase occurred in lifetime-, annual-, and monthly-use rates of LSD, in 1993, according to the annual NIDA high school senior survey. In 1992, an increase in LSD-related arrests occurred, as did seizures of larger...
Psychopharmacology
April 1995
V J Watts, C P Lawler, D R Fox et al.
The hallucinogenic effects of lysergic acid diethylamide (LSD) have been attributed primarily to actions at serotonin receptors. A number of studies conducted in the 1970s indicated that LSD also has activity at dopamine (DA) receptors. These latter studies are difficult to interpret, however, because they were completed before the recognition of two pharmacologically distinct DA receptor...
Choice Reviews Online
April 1, 1995
22 citations
The facts about LSD A new book on LSD is long overdue, but this was worth waiting for. The material is thoughtful and carefully prepared, and the collection brings the topic into the 1990s. The book should be in every library, and read by everyone interested in the American drug scene. --James A. Inciardi, Ph.D., professor and director, Center for Drug and Alcohol Studies, University of...
Journal of Medicinal Chemistry
March 1, 1995
Aaron Monte, Danuta Marona‐lewicka, Arthi Kanthasamy et al.
25 citations
The 3-pentyl-, (R)- and (S)-2-pentyl-, 2-hexyl-, and 2-heptylamides of d-lysergic acid were synthesized and evaluated in biochemical and behavioral assays for LSD-like activity. In radioligand competition studies, the (R)-lysergamides were consistently more potent than the (S)-amides in displacing [3H]ketanserin from 5-HT2A receptors in rat cortical homogenate and in displacing [3H]-8-OH-DPAT...
The Journal of Pediatrics
November 1, 1994
Two adolescents with a long history of abuse of lysergic acid diethylamide (LSD) and symptoms consistent with major depressive disorder, on initiation of antidepressant therapy with selective serotonin reuptake inhibitor agents, had the new onset or worsening of LSD flashback syndrome. The similarity in neuroreceptor physiology for both LSD and serotonin suggests that the LSD flashback syndrome...
Pharmacology, Biochemistry, and Behavior
September 1994
P A Palumbo, Jerrold C Winter
Two groups of rats were trained with the 5-HT2 agonists 2,5-dimethoxy-4-methylamphetamine (DOM) or lysergic acid diethylamide (LSD) in a two-lever discrimination task. Tests of generalization and antagonism were then carried out with clozapine. DOM did not generalize to clozapine. Partial antagonism of DOM was observed with 0.3, 1, and 2 mg/kg clozapine and statistically significant full...