Journal of Biological Chemistry
June 21, 1996
N Almaula, Barbara J. Ebersole, D Zhang et al.
147 citations
Like other amine neurotransmitters that activate G-protein-coupled receptors, 5-hydroxytryptamine (5-HT) binds to the 5-HT2A receptor through the interaction of its cationic primary amino group with the conserved Asp3.32(155) in transmembrane helix 3. Computational experiments with a 5-HT2A receptor model suggest that the same functional group of 5-hydroxytryptamine also forms a hydrogen bond...
Neuropsychopharmacology
June 1996
K R Bonson, J W Buckholtz, D L Murphy
This study investigates the possible interactions of antidepressant agents and hallucinogens in humans through structured interviews using a standardized questionnaire. Volunteer subjects recruited through announcements placed on the Internet or other sources were asked to describe the somatic, hallucinatory, and psychological effects of self-administered LSD prior to and during chronic...
Journal of Clinical Psychopharmacology
June 1, 1996
Henry David Abraham, Anitra Mamen
50 citations
Risperidone, a novel antipsychotic agent, is an antagonist of postsynaptic serotonin-2 and dopamine D2 receptors. In certain individuals, the hallucinogenic drug lysergic acid diethylamide (LSD) is associated with apparently lifelong continuous visual disturbances, characterized in DSM-IV as hallucinogen-persisting perception disorder (HPPD). Because the hallucinogenic mechanism of LSD is known...
Life Sciences
1996
David Fiorella, Scott Helsley, R A Rabin et al.
The present investigation examined the interaction between fluoxetine enantiomers and LSD in rats trained with LSD as a discriminative stimulus. The dose response relationships for LSD alone and in combination with either (+)- or (-)-fluoxetine were determined. In both instances, the LSD dose response relationship was shifted to the left. However, statistical significance was observed only for...
Behavioural Brain Research
1996
K R Bonson, D L Murphy
This study sought to investigate possible interactions between antidepressant agents and lysergic acid diethylamide (LSD) in humans through the use of retrospective questionnaires. Ten subjects were identified who used LSD during chronic (3 weeks or longer) periods of antidepressant administration. These subjects were asked to describe the phenomenological effects of self-administered...
Nordic Journal of Psychiatry
1996
Jørgen Due Madsen, Torbjørg Øyslebø, Asle Hoffart
7 citations
Psychotherapy with LSD was used at Modum Bads Nervesanatorium (MBN) from 1961, and In 968 a questionnaire was sent out to the first 300 patients treated, in which they were to state results and experience of the treatment, psychic condition, and treatment after the hospitalization at MBN. Because the question whether LSD influenced the chromosomes was topical at that time, a major part of the...
Journal of Neuropathology & Experimental Neurology
1996
Nataša Zec, James J. Filiano, Ashok Panigrahy et al.
31 citations
The ontogeny of serotonin receptors in the human brainstem is largely unknown, despite the putative roles of serotonin in neural development, synaptic transmission, brainstem modulation of vegetative functions, and clinical disorders of serotonergic function. This study provides baseline information about the quantitative distribution of [3H]LSD binding to serotonergic receptors (5-HT1A-1D,...
Behavioral Neuroscience
1996
Linda A. Parker
41 citations
The hedonic properties of lysergic acid diethylamide (LSD) were assessed using the place conditioning, taste reactivity, and taste avoidance tests. LSD produced a conditioned place preference, but only at the highest dose tested (0.2 mg/kg). A single preexposure to the conditioning chamber (latent inhibition) prevented the establishment of a place preference. When paired with sucrose, doses of...
Archives of Ophthalmology
1996
Aki Kawasaki
64 citations
We have described three patients in whom persistent palinopsia developed following ingestion of LSD. Clinicians should inquire about past LSD use in all patients who initially have seemingly spontaneous, isolated palinopsia. Recognition of this distinctive clinical syndrome associated with LSD use might avoid unnecessary anxiety and excessive diagnostic tests for patients with this disorder.
Nordic Journal of Psychiatry
1996
Jørgen Due Madsen, Asle Hoffart
7 citations
Psychotherapeutic treatment with hallucinogens, usually called psycholytic treatment, was used at Modum Bads Nervesanatorium (MBN) on inpatients from 1961 to 1976. The hallucinogens used were LSD, psilocybin, and CZ 74. The indications and the treatment procedure at MBN are described. From 1961 to 1976, 379 patients received 2205 psycholytic treatments, mostly with LSD. From 1970 to 1976, only...