Potentiation of LSD-induced stimulus control by fluoxetine in the rat.
David Fiorella, Scott Helsley, R A Rabin, Jerrold C Winter
Life Sciences 1996 DOI: 10.1016/0024-3205(96)00490-0 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal behavioral pharmacology experiment (drug discrimination study) Peer reviewed |
|---|---|
| Population | Rats trained with LSD as a discriminative stimulus |
| Interventions | LSD (-)-fluoxetine |
| Topics | LSD |
| Keywords | Animals Rats, inbred f344 Fluoxetine Behavior, animal Drug interactions Stereoisomerism Male |
| Key findings | Acute administration of either fluoxetine enantiomer shifted the LSD dose-response relationship to the left, but the potentiation was statistically significant only for (+)-fluoxetine. The authors conclude that fluoxetine potentiates LSD's discriminative stimulus effects, consistent with anecdotal human reports of LSD-SSRI interactions. |
Abstract
The present investigation examined the interaction between fluoxetine enantiomers and LSD in rats trained with LSD as a discriminative stimulus. The dose response relationships for LSD alone and in combination with either (+)- or (-)-fluoxetine were determined. In both instances, the LSD dose response relationship was shifted to the left. However, statistical significance was observed only for the (+)- enantiomer. It is concluded that the effects of LSD as a discriminative stimulus are potentiated by the acute administration of fluoxetine. These results are consistent with anecdotal reports of interactions between LSD and acutely administered SSRIs in humans.
Comparable studies
Other preclinical and animal studies on LSD, most cited first.
Citations in the library
Cited by 13
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- Predicting Reactions to Psychedelic Drugs: A Systematic Review of States and Traits Related to Acute Drug Effects. ACS Pharmacology & Translational Science March 5, 2021
- Therapeutic (Sub)stance: Current practice and therapeutic conduct in preparatory sessions in substance-assisted psychotherapy—A systematized review Journal of Psychopharmacology October 20, 2022
- The acute effects of monoamine reuptake inhibitors on the stimulus effects of hallucinogens. Pharmacology, Biochemistry, and Behavior July 1, 1999
- Content analysis of Reddit posts about coadministration of selective serotonin reuptake inhibitors and psilocybin mushrooms. Psychopharmacology August 1, 2024
and 8 more in the library
Cites 3
- Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Science August 16, 1968
- Chronic administration of serotonergic antidepressants attenuates the subjective effects of LSD in humans. Neuropsychopharmacology June 1996
- The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs. I: Antagonist correlation analysis. Psychopharmacology October 1995