A pilot open study was conducted in order to evaluate the efficacy of clonidine in the treatment of LSD-induced hallucinogen persisting perception disorder (HPPD). Eight patients fulfilled entrance criteria. All complained of HPPD for at least 3 months and were drug free at least 3 months. They received fixed low doses of clonidine, 0.025 mg, three times a day for 2 months. They were evaluated...
The enantiomers of 3-(N-methylpyrrolidin-2-ylmethyl)-5-methoxyindole, 1, and 3-(N-methylpyrrolidin-2-ylmethyl)-4-hydoxyindole, 3, were prepared using an asymmetric synthesis that employed (+)- or (-)-proline. A new approach was developed that had certain advantages over the synthesis originally reported for the isomers of 1. (+/-)-3-(N-Methylpyrrolidin-3-yl)-4-hydroxyindole, 5, was also...
Abstract Both the phenethylamine hallucinogen (–)‐1‐2,5‐dimethoxy‐4‐bromophenyl‐2‐aminopropane (DOB), a selective serotonin 5‐HT 2A,2C receptor agonist, and the indoleamine hallucinogen d ‐lysergic acid diethylamide (LSD, which binds to 5‐HT1A, 1B, 1D, 1E, 1F, 2A, 2C, 5, 6, 7, dopamine D 1 and D 2 , and α 1 and α 2 adrenergic receptors), but not their non‐hallucinogenic congeners, inhibited...
For more than 40 years the hallucinogen lysergic acid diethylamide (LSD) has been known to modify serotonin neurotransmission. With the advent of molecular and cellular techniques, we are beginning to understand the complexity of LSD's actions at the serotonin 5-HT2 family of receptors. Here, we discuss evidence that signaling of LSD at 5-HT2C receptors differs from the endogenous agonist...
Lysergic Acid Diethylamide (LSD) is a hallucinogenic drug that received considerable attention in the 1960's and early 1970's. It produced a wide variety of psychological phenomena, including a variety of perceptual disturbances which would manifest among some users long after the drug had left the system. These phenomena were commonly referred to as "flashbacks" and may have been largely...
NeuronMarch 1, 1999R. Grailhe, C. Waeber, S. Dulawa et al.
In order to determine the distribution and function of the 5-HT5A serotonin receptor subtype, we generated knockout mice lacking the 5-HT5A gene. Comparative autoradiography studies of brains of wild-type (wt) and 5-HT5A knockout (5A-KO) mice revealed the existence of binding sites with high affinity for [125I]LSD that correspond to 5-HT5A receptors and that are concentrated in the olfactory...
Im dargestellten Fall geht es um eine 27jährige Patientin, die bis zum Zeiptunkt des positiven Schwangerschaftstests, entsprechend 74/7 Schwangerschaftswochen (p.c.), täglich einen Joint (Cannabis) und 20 Zigaretten (Tabak) geraucht hat. Am 20. Tag p.c. erfolgte ein LSD-Minitrip. Das Sichten der Literatur ergab beim Tier in vitro Chromosomenaberrationen mit LSD. Beim Menschen stehen...
Neuropsychobiology1999Jeanette Sigurdh, Olav Spigset, Per O. Allard et al.
Possible age effects on binding of [3H]lysergic acid diethylamide ([3H]LSD) to serotonin 5-HT2A receptors and of [3H]paroxetine to serotonin uptake sites were studied in platelets from healthy children (11–12 years of age), adolescents (16–17 years of age) and adults. Significant overall age effects were found both for the number of binding sites (Bmax) for [3H]LSD binding (p < 0.001), the...
While sitting alone in complete darkness, 3 participants who had ingested psychotropic concentrations of lysergic acid diethylamide reported diffuse blobs of white, purplish, or greenish-yellow lights as two horseshoe magnets rotated at 0.5 Hz. The experiences were not reported when the magnets were stationary or removed from the apparatus. The estimated peak-to-peak variation in field strength...
A controlled study was undertaken to determine the stability of LSD in pooled urine samples. The concentrations of LSD in urine samples were followed over time at various temperatures, in different types of storage containers, at various exposures to different wavelengths of light, and at varying pH values. LSD concentrations were measured quantitatively by the Abuscreen RIA and by HPLC using a...