The ontogeny of serotonin receptors in the human brainstem is largely unknown, despite the putative roles of serotonin in neural development, synaptic transmission, brainstem modulation of vegetative functions, and clinical disorders of serotonergic function. This study provides baseline information about the quantitative distribution of [3H]LSD binding to serotonergic receptors (5-HT1A-1D,...
The relation between body and mind is one of the oldest riddles that has puzzled mankind. That material and mental events may interact is accepted even by the law: our mental capacity to concentrate on the task can be seriously reduced by drugs. Physical and chemical processes may act upon the mind; and when we are writing a difficult letter, our mind acts upon our body and, through a chain of...
This study was undertaken to examine the possible cytologic action of LSD-25, lysergic acid diethylamide, on nervous tissue. Organotypic cultures of mouse cerebellum were exposed to LSD in their nutrient medium for periods up to 53 hours. Light-microscopically, at a dose of 10-3 M, coarse granules developed in the cytoplasm of mature neurons and in the cytoplasm of cells in the outgrowth...