Abuse of synthetic drugs is an emerging trend in substance abuse. Identification of exposure to such chemicals is often difficult due to the paucity of specific laboratory assays. One such group of compounds is the 2C class of phenethylamines that include 2-(4-lodo-2, 5-dimethoxyphenyl)-N-I[(2-methyoxyphenyl)methyl]ethanamine, known as 251-NBOMe or the street names “Smiles” and “N-Bomb.” This...
NeurologyApril 8, 2014Yoshie Umemura, Thomas A. Andrew, Valerie L. Jacobs et al.
OBJECTIVE: To describe a fatal outcome due to ingestion of a new designer drug, 25I-NBOMe. BACKGROUND: Abuse of synthetic drugs has been on the rise, and many are sold over-the-counter as bath salts and fertilizer. Identification of the exposure to such chemicals is often difficult due to the paucity of available specific laboratory assays. 25I-NBOMe stands for...
The ontogeny of serotonin receptors in the human brainstem is largely unknown, despite the putative roles of serotonin in neural development, synaptic transmission, brainstem modulation of vegetative functions, and clinical disorders of serotonergic function. This study provides baseline information about the quantitative distribution of [3H]LSD binding to serotonergic receptors (5-HT1A-1D,...