Neuroendocrinology
March 26, 2008
Anni Sietnieks, Bengt J. Meyerson
11 citations
Copulatory behavior in the ovariectomized rat, i.e. the lordosis response (LR) on being mounted by a male, can be induced by administration of either estrogen alone or estrogen followed by progesterone. LR has been shown to be inhibited by lysergic acid diethylamide (LSD) in certain doses (≥50 μg/kg) and by Levo-5-hydroxytryptophan (L-5-HTP) (≥2.5 mg/kg). This effect was recently found to be...
Bohn Stafleu van Loghum eBooks
2008
Hylke K E Vervaeke
1 citation
Psychedelische paddenstoelen worden al duizenden jaren gebruikt door de mensheid. In grotten op het Tassiliplateau in Algerije zijn spectaculaire rotstekeningen teruggevonden van minstens 5500 jaar oud. De bekendste beeldt een man uit met een bijenho
Pharmacology, Biochemistry, and Behavior
January 2008
C M Krall, J B Richards, R A Rabin et al.
Based upon extensive studies in the rat, it has been suggested that stimulus control by LSD is mediated by 5-HT2A receptors, with serotonergic receptors of the 5-HT1A and 5-HT2C subtypes playing modulatory roles. In genetically modified mice lacking the serotonin transporter (SERT), 5-HT2A receptor density is decreased and, at a functional level, the head-twitch response following the...
Neuropsychobiology
2008
Paolo Fusar‐poli, Stefan Borgwardt
7 citations
to experience 'an extremely stimulated imagination' caused by an accidental ingestion of LSD.Three days later, on April 19, 1943, he decided to verify his results by intentionally ingesting LSD.This day has become known as 'Bicycle Day' as Hofmann experienced an incredible bicycle ride on his way home from the lab.LSD was initially hailed as a wonder drug for use in psychoanalysis, particularly...
Pharmacology, Biochemistry, and Behavior
October 2007
Danuta Marona‐lewicka, David E Nichols
Activation of 5-HT(2A) receptors is thought to mediate the hallucinogenic effects of LSD. Nevertheless, in a previous report we provided evidence that a delayed temporal phase of the behavioral pharmacology of LSD is mediated by D(2)-like dopamine receptor stimulation. In this study rats were trained to discriminate LSD with either a 30 min preinjection time (LSD-30, N=12) or a 90 min...
The Biochemist
April 1, 2007
Erika Dyck
2 citations
In April 1943, Dr Albert Hofmann, a Swiss biochemist, dissolved a few micrograms of a newlysynthesized drug, d-lysergic acid diethylamide (LSD), in a glass of water and drank it. Three-quarters of an hour later, he recorded a growing dizziness, some visual disturbances and a marked desire to laugh. After about an hour he asked his assistant to call a doctor and accompany him home from his...
Journal of Pharmacology and Experimental Therapeutics
February 2007
Paul J Gresch, Robert J. Barrett, Elaine Sanders‐bush et al.
d-Lysergic acid diethylamide (LSD), an indoleamine hallucinogen, produces profound alterations in mood, thought, and perception in humans. The brain site(s) that mediates the effects of LSD is currently unknown. In this study, we combine the drug discrimination paradigm with intracerebral microinjections to investigate the anatomical localization of the discriminative stimulus of LSD in rats....
International Anesthesiology Clinics
2007
George A. Mashour
13 citations
University of Michigan Medical School Ann Arbor, Michigan A version of this article appeared in the Bulletin of Anesthesia History (July, 2005). The author thanks Dr Edward Lowenstein, Dr George Battit, Dr Bucknam McPeek, and Dr Warren Zapol of the Massachusetts General Hospital and Dr Johnathan Moreno of the University of Virginia for their interest and helpful contributions to this project....
Developmental Neurorehabilitation
2007
Jeff Sigafoos, Vanessa A. Green, Chaturi Edrisinha et al.
43 citations
Between 1959 and 1974, several groups of researchers issued reports on the use of d-Lysergic Acid Diethylamide (LSD) in the treatment of children with autism. This paper reviews that literature to consider how the authors justified these studies, as well as their methods, results, and conclusions. The justification for using LSD was often based on the default logic that other treatment efforts...
The Chemical Educator
December 1, 2006
G. Wayne Craig, George B. Kauffman
Albert Hofmann’s discovery of LSD by “chance or by a higher plan” led to a revolution in the pharmaceutical industry, inspiring research to understand how a chemical’s structure is recognized and how this recognition triggers a physiological response. The incredible potency of this drug challenged the conventional lock-and-key model that Emil Fischer had proposed for enzymes. In fact, the...