Psychopharmacology
April 2009
Jerrold C Winter
Although man's first encounters with hallucinogens predate written history, it was not until the rise of the sister disciplines of organic chemistry and pharmacology in the nineteenth century that scientific studies became possible. Mescaline was the first to be isolated and its chemical structure determined. Since then, additional drugs have been recovered from their natural sources and...
Fortschritte der Neurologie · Psychiatrie
February 2009
M K Bernhard, K Ulrich
Recurrent disturbances of vision associated with headaches are typical signs of a migraine. A 15-year-old girl suffered from common migraine. The patient had a headache and nausea five days after a first and proved intake of LSD. Shortly later, a complete blindness of both eyes developed within seconds. These symptoms continued for 48 hours. As the pupillar reactions were intact the findings...
Health and History
2009
Mathew T Martin-Iverson
Health& History 1112 2009 159 has to sort through a lot of other stuff to get it.He has some trouble keeping onmessage, often diverting tonon-related areas of psychiatric history. Then, we have to deal with his well-known opinions of the dreaded drug companies who are undoubtedly a part of the history, but could have been dealt with more objectively. I rather enjoyed his interludes into the...
cIRcle (University of British Columbia)
2009
Erik D Anderson
The controversy surrounding the use of LSD as an adjunct to psychotherapy for alcoholics in Saskatchewan has not been explored by social or medical historians. From 1950 to 1967, Saskatchewan psychiatrists developed new treatments for chronic alcoholism by using LSD on themselves, on volunteers and finally on patients. Despite early success and praise, the use of LSD in psychotherapy was later...
The Sixties
December 1, 2008
Peter Coyote
10.1080/17541320802457160-UF0001 Dr Albert Hofmann, at age 100, in Basel, Switzerland in 2006. The authors cited laboratory experiments with subjects in an induced‐trance state which suggested that...
Contemporary Justice Review
November 18, 2008
Adam Jacobs
3 citations
Recently the use of hallucinogens in therapy has resurfaced in clinical research. Decades after dismissing Timothy Leary for his experiments, Harvard approved clinical trials using psilocybin (mushrooms) in therapy with terminally ill patients. This article re‐evaluates the research on LSD as a therapeutic element. A re‐assessment of the earlier legal research on hallucinogenic therapy reveals...
CNS Neuroscience & Therapeutics
November 11, 2008
Torsten Passie, John H. Halpern, Dirk O. Stichtenoth et al.
459 citations
Lysergic acid diethylamide (LSD) was synthesized in 1938 and its psychoactive effects discovered in 1943. It was used during the 1950s and 1960s as an experimental drug in psychiatric research for producing so‐called “experimental psychosis” by altering neurotransmitter system and in psychotherapeutic procedures (“psycholytic” and “psychedelic” therapy). From the mid 1960s, it became an illegal...
Deviant Behavior
July 1, 2008
Erich Goode
49 citations
Abstract Critics of the moral panic dismiss this extremely useful, often-cited, and durable concept on the basis of inapplicable criteria. Drawing on the example of LSD use in the sixties, these critics mistakenly assume that the disaster analogy is apt, insisting that the threat to society, and society's responses, be very much like victims trapped in a burning building. In addition to the...
British Journal of Pharmacology
June 2, 2008
Andrew R. Green
30 citations
The vasoconstrictor substance named serotonin was identified as 5‐hydroxytryptamine (5‐HT) by Maurice Rapport in 1949. In 1951, Rapport gave Gaddum samples of 5‐HT substance allowing him to develop a bioassay to both detect and measure the amine. Gaddum and colleagues rapidly identified 5‐HT in brain and showed that lysergic acid diethylamide (LSD) antagonized its action in peripheral tissues....
European Journal of Pharmacology
March 31, 2008
Chad J Reissig, Richard A. Rabin, Jerrold C Winter et al.
Induction of mRNA or protein for immediate-early genes, such as c-fos, is used to identify brain areas, specific cell types, and neuronal circuits that become activated in response to various stimuli including psychoactive drugs. The objective of the present study was to identify the cell types in the prefrontal cortex in which lysergic acid diethylamide (d-LSD) induces c-Fos expression....