13 papers in the library · 1,396 citations · publishing 2008-2026
Schizophr Res Cogn June 11, 2026 Kristina Ballestad Gundersen, Tina Dam Kristensen, Alberte C.E. Jeppesen et al.
Comparative profiles of anomalous self-experiences and social cognition in clinical high risk for psychosis and autism spectrum disorder.
Eur Neuropsychopharmacol November 7, 2025 Mikkel Højlund, Helin Y. Kafali, Begüm Kırmızı et al. 12 citations
Efficacy, all-cause discontinuation, and safety of serotonergic psychedelics and MDMA to treat mental disorders: A living systematic review with meta-analysis.
European Journal of Neuroscience November 1, 2025 Paolo La‐torraca‐vittori, Livio Tarchi, Elisa Arrigo et al. 1 citation
Despite a renewed scientific interest in lysergic acid diethylamide (LSD), its local neural effects remain underexplored. This functional magnetic resonance imaging (fMRI) study explored and compared LSD-induced changes in local activity (amplitude of low-frequency fluctuations: ALFF) and local connectivity (regional homogeneity: ReHo), assessing their relationship to regional receptor density....
CNS Spectrums December 1, 2024 Mauro Scala, Chiara Fabbri, Paolo Fusar‐poli et al. 8 citations
The revival of psilocybin in psychopharmacological research heralds a potential paradigm shift for treating mood and anxiety disorders, and other psychiatric conditions beyond the psychotic spectrum. This critical review evaluates current evidence on psilocybin's efficacy, juxtaposing potential benefits with the practical aspects of psychedelic-assisted psychotherapy (PAP) and the...
Psychopathology 2024 Milena Mancini, Cecilia Maria Esposito, Andrés Estradé et al. 6 citations
Abnormal self-experiences are a common feature of major depression despite their absence from current diagnostic manuals. Current diagnostic criteria leave us with an impoverished conception of depressive disorders, and they fail to exploit the diverse experiential alterations that might be useful for understanding and diagnosing patients, and last but not least for explaining the aetiology of...
World psychiatry : official journal of the World Psychiatric Association (WPA) June 1, 2022 Paolo Fusar‐poli, Andrés Estradé, Giovanni Stanghellini et al. 225 citations
Psychosis is the most ineffable experience of mental disorder. We provide here the first co-written bottom-up review of the lived experience of psychosis, whereby experts by experience primarily selected the subjective themes, that were subsequently enriched by phenomenologically-informed perspectives. First-person accounts within and outside the medical field were screened and discussed in...
Psychological Medicine October 1, 2012 Zerrin Atakan, Sagnik Bhattacharyya, Paul Allen et al. 54 citations
BACKGROUND: Cannabis can induce transient psychotic symptoms, but not all users experience these adverse effects. We compared the neural response to Δ9-tetrahydrocannabinol (THC) in healthy volunteers in whom the drug did or did not induce acute psychotic symptoms. Method In a double-blind, placebo-controlled, pseudorandomized design, 21 healthy men with minimal experience of cannabis were...
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology June 2011 Toby T Winton-Brown, Paul Allen, Sagnik Bhattacharyya et al.
Although the effects of cannabis on perception are well documented, little is known about their neural basis or how these may contribute to the formation of psychotic symptoms. We used functional magnetic resonance imaging (fMRI) to assess the effects of Delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) during visual and auditory processing in healthy volunteers. In total, 14 healthy...
The International Journal of Neuropsychopharmacology September 24, 2009 Paolo Fusar‐poli, Paul Allen, Sagnik Bhattacharyya et al. 165 citations
Cannabis sativa, the most widely used illicit drug, has profound effects on levels of anxiety in animals and humans. Although recent studies have helped provide a better understanding of the neurofunctional correlates of these effects, indicating the involvement of the amygdala and cingulate cortex, their reciprocal influence is still mostly unknown. In this study dynamic causal modelling (DCM)...
Psychological Medicine July 23, 2009 Rocío Martín‐Santos, Ana B. Fagundo, José Alexandre S. Crippa et al. 207 citations
BACKGROUND: We conducted a systematic review to assess the evidence for specific effects of cannabis on brain structure and function. The review focuses on the cognitive changes associated with acute and chronic use of the drug. METHOD: We reviewed literature reporting neuroimaging studies of chronic or acute cannabis use published up until January 2009. The search was conducted using Medline,...
Archives of General Psychiatry April 1, 2009 Sagnik Bhattacharyya, Paolo Fusar‐poli, Stefan Borgwardt et al. 250 citations
CONTEXT: Cannabis sativa use can impair verbal learning, provoke acute psychosis, and increase the risk of schizophrenia. It is unclear where C. sativa acts in the human brain to modulate verbal learning and to induce psychotic symptoms. OBJECTIVES: To investigate the effects of 2 main psychoactive constituents of C. sativa, Delta9-tetrahydrocannabinol (Delta9-THC) and cannabidiol, on regional...
Archives of General Psychiatry 2009 Paolo Fusar‐poli, José A. Crippa, Sagnik Bhattacharyya et al. 461 citations
CONTEXT: Cannabis use can both increase and reduce anxiety in humans. The neurophysiological substrates of these effects are unknown. OBJECTIVE: To investigate the effects of 2 main psychoactive constituents of Cannabis sativa (Delta9-tetrahydrocannabinol [Delta9-THC] and cannabidiol [CBD]) on regional brain function during emotional processing. DESIGN: Subjects were studied on 3 separate...
Neuropsychobiology 2008 Paolo Fusar‐poli, Stefan Borgwardt 7 citations
to experience 'an extremely stimulated imagination' caused by an accidental ingestion of LSD.Three days later, on April 19, 1943, he decided to verify his results by intentionally ingesting LSD.This day has become known as 'Bicycle Day' as Hofmann experienced an incredible bicycle ride on his way home from the lab.LSD was initially hailed as a wonder drug for use in psychoanalysis, particularly...