Further evidence that the delayed temporal dopaminergic effects of LSD are mediated by a mechanism different than the first temporal phase of action.
Danuta Marona‐lewicka, David E Nichols
Pharmacology, Biochemistry, and Behavior October 2007 DOI: 10.1016/j.pbb.2007.06.001 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Sample size | 25 |
| Population | Rats trained to discriminate LSD from saline |
| Intervention | LSD |
| Topics | LSD |
| Key findings | Classical hallucinogens substituted only in rats trained with a 30-minute LSD pre-injection time, while dopamine receptor agonists substituted only in rats trained with a 90-minute pre-injection time, supporting the claim that delayed LSD effects are mediated by dopaminergic activation. |
Abstract
Activation of 5-HT(2A) receptors is thought to mediate the hallucinogenic effects of LSD. Nevertheless, in a previous report we provided evidence that a delayed temporal phase of the behavioral pharmacology of LSD is mediated by D(2)-like dopamine receptor stimulation. In this study rats were trained to discriminate LSD with either a 30 min preinjection time (LSD-30, N=12) or a 90 min preinjection time (LSD-90, N=13) from saline, using a two-lever, food-reinforced operant conditioning task. We then tested a large number of agonists and antagonists belonging to distinct pharmacological classes in these animals. As anticipated, classical hallucinogens such as psilocin and mescaline substituted only in LSD-30 rats, and not in LSD-90 rats. The dopamine receptor agonists ABT-724, aripiprazole, dihydrexidine, WAY 100635, and SKF 38393, fully or partially mimicked LSD-90, but not LSD-30. The results reported here support and extend our previous conclusion that the delayed temporal effects of LSD are mediated by activation of a dopaminergic system.
Comparable studies
Other preclinical and animal studies on LSD, most cited first.
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Cites 24
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