Social History of Medicine
July 17, 2006
Erika Dyck
87 citations
Journal Article ‘Hitting Highs at Rock Bottom’: LSD Treatment for Alcoholism, 1950–1970 Get access Erika Dyck Erika Dyck * *Department of History and Classics/Division of Studies for Medical Education, 2–2 Tory Building , University of Alberta , Edmonton, Alberta, T6G 2H4 , Canada . E-mail: Erika.dyck@ualberta.ca Search for other works by this author on: Oxford Academic PubMed Google Scholar...
Neurology
June 26, 2006
R. Andrew Sewell, John H. Halpern, Harrison G. Pope
259 citations
The authors interviewed 53 cluster headache patients who had used psilocybin or lysergic acid diethylamide (LSD) to treat their condition. Twenty-two of 26 psilocybin users reported that psilocybin aborted attacks; 25 of 48 psilocybin users and 7 of 8 LSD users reported cluster period termination; 18 of 19 psilocybin users and 4 of 5 LSD users reported remission period extension. Research on...
Psychiatrische Praxis
May 1, 2006
Raoul M Hecker
Anlässlich des 100. Geburtstages des LSD-Drogen-Erfinders Albert Hofmann veranstaltete die Gaia Media Stiftung einen dreitägigen Kongress im Baseler Kongresszentrum. Insgesamt kamen über 1600 Besucher bei doch recht hohen Eintrittspreisen und 200 Pressevertreter zu der Tagung. Atmosphärisch interessant gestaltete sich schon der Vorraum des Zentrums, in dem psychonautische Klänge und eine...
Psychopharmacology
October 2005
Chad J Reissig, Justin R Eckler, R A Rabin et al.
It has been suggested that the 5-HT1A receptor plays a significant modulatory role in the stimulus effects of the indoleamine hallucinogen lysergic acid diethylamide (LSD). The present study sought to characterize the effects of several compounds with known affinity for the 5-HT1A receptor on the discriminative stimulus effects of LSD. Twelve male Fischer 344 rats were trained in a two-lever,...
Molecular Psychiatry
September 1, 2005
P Seeman, F Ko, T Tallerico
Although phencyclidine and ketamine are used to model a hypoglutamate theory of schizophrenia, their selectivity for NMDA receptors has been questioned. To determine the affinities of phencyclidine, ketamine, dizocilpine and LSD for the functional high-affinity state of the dopamine D2 receptor, D2High, their dissociation constants (Ki) were obtained on [3H]domperidone binding to human cloned...
Pharmacology, Biochemistry, and Behavior
August 2005
Jerrold C Winter, A K Kieres, M D Zimmerman et al.
Drug-induced stimulus control has proven to be a powerful tool for the assessment of a wide range of psychoactive drugs. Although a variety of species has been employed, the majority of studies have been in the rat. However, with the development of techniques which permit the genetic modification of mice, the latter species has taken on new importance. Lysergic acid diethylamide [LSD], the...
Science Fiction Studies
July 1, 2005
Andrew M. Butler
Philip K. Dick has a reputation in some circles as an acid-crazed visionary, which was more the result of his self-publicity than his particular drug habits. During the 1960s he repeatedly discussed his LSD use in fanzine articles and letters, and he incorporated it as a plot device in a novel that was to become Lies, Inc. (1983). The textual history of this novel, and its precursor version,...
Psychopharmacology
July 2005
Danuta Marona‐lewicka, Ronald A Thisted, David E Nichols
The effect of LSD in humans has been described as occurring in two temporal phases. The behavioral effects in rats also occur in two temporal phases: an initial suppression of exploration followed by increased locomotor activity. We decided to investigate this phenomenon from the perspective that the pharmacology might have relevance to the neurochemical mechanisms underlying psychosis....
The Canadian Journal of Psychiatry
June 1, 2005
Erika Dyck
88 citations
In the popular mind, d-lysergic acid diethylamide (LSD) research in psychiatry has long been associated with the CIA-funded experiments conducted by Ewen Cameron at the Allen Memorial Institute in Montreal, Quebec. Despite this reputation, a host of medical researchers in the post World War II era explored LSD for its potential therapeutic value. Some of the most widespread trials in the...
Neuropsychopharmacology
March 9, 2005
Paul J Gresch, Randy L Smith, Robert J. Barrett et al.
62 citations
Tolerance is defined as a decrease in responsiveness to a drug after repeated administration. Tolerance to the behavioral effects of hallucinogens occurs in humans and animals. In this study, we used drug discrimination to establish a behavioral model of lysergic acid diethylamide (LSD) tolerance and examined whether tolerance to the stimulus properties of LSD is related to altered serotonin...