Integrating advanced pharmaceutical innovations and artificial intelligence (AI) offers transformative potential for psychiatric care. This Patent Highlight reviews novel therapeutic strategies, including the synergistic use of monoamine antidepressants and short-duration psychedelics, alongside AI-driven behavioral efficacy tracking. The combination of selective serotonin reuptake inhibitors...
Abstract Background Recent clinical trials reveal that serotonergic psychedelics, including the prototypical hallucinogen lysergic acid diethylamide (LSD), present a promising potential for treating psychiatric disorders, including treatment-resistant depression. LSD is a potent 5-HT receptors ligand endowed with high affinity for most of all 5-HT subtypes and is regularly used as a valuable...
According to some theories of emotion regulation, dreams could modify negative emotions and ultimately reduce their intensity. We introduce here the idea of cathartic dream, a specific and separate type of emotional dream, which is characterized by a dynamic plot with emotional twists, and where negative emotions are expressed and ultimately decreased. This process would reflect psychological...
Abstract According to L.A. Paul, undergoing an experience is transformative if we learn something we cannot learn without having the experience and if it substantially changes our point of view. While the implications of transformative experiences have primarily been discussed in the context of rational choice, their underlying concept has also proven fruitful in the context of unchosen...
[pt] A ayahuasca é uma infusão psicoativa utilizada como enteógeno há séculos, com pesquisas recentes indicando seu potencial como um tratamento promissor para certos transtornos clínicos. Apesar do crescente corpo de literatura científica sobre seus efeitos, ainda há uma escassez de estudos que investiguem as experiências subjetivas de usuários ingênuos de ayahuasca. O primeiro estudo desta...
Abstract Background and Aims Networks of so-called underground, or illegal, psilocybin mushroom practitioners are popularly known to exist, though few systematic investigations of their practices have been conducted. We sought to uncover the experiences of a hidden community of psilocybin practitioners in order to inform scientific and policy dialogues about safe and effective practices in this...
Introduction Health is a multidimensional phenomenon encompassing physical, mental, and social well-being, all of which are deeply interconnected. The COVID-19 pandemic highlighted the importance of mental and social health, as rates of loneliness, depression, and anxiety surged. Mindfulness practices, such as Shambhavi Mahamudra Kriya (SMK), have gained attention for their potential to enhance...
Hallucinogen-persisting Perception Disorder (HPPD) is a rare condition characterized by the re-experiencing of one or more perceptual symptoms that an individual experienced while intoxicated with a hallucinogenic substance when the individual is sober. While there are several case reports of HPPD in adult patients, there is a scarcity of documented cases in children and adolescents. The...
This article explores the potential of the novel antidepressant dextromethorphan-bupropion in addressing treatment-resistant depression (TRD). Traditional approaches, including selective serotonin reuptake inhibitors and serotonin and norepinephrine reuptake inhibitors, alongside antipsychotic agents, often prove insufficient. Amid a global surge in TRD post-COVID-19, dextromethorphan-bupropion...
ABSTRACT Adverse impacts on children in home isolation during the COVID-19 pandemic have been documented. These impacts include increased loneliness, anxiety, depression, posttraumatic disorder, and heightened risk of psychiatric illness. The present study introduces a proto-theoretical model of stress, psychophysiology, and coping to explain this phenomenon. A focus of the research is on...