Psychiatry Research
January 29, 2025
Felix Müller, Thomas Sauer, Corina Hänny et al.
11 citations
• A 60-year-old man with recurrent depression and history of delusions died after psilocybin-assisted therapy. • Psilocybin-triggered delusions and emotional dysregulation may have contributed. • Weak therapeutic alliance hindered assessment of patient's internal state. • Delusional symptoms may contraindicate psychedelic interventions. • This case emphasizes the need for thorough assessment...
Cell Biology and Toxicology
January 29, 2025
Xiaoming Ji, Zhimin Huang, Chenming Zhou et al.
6 citations
Esketamine, a newly developed antidepressant, is the subject of this research which seeks to explore its impact on depressive symptoms in neuropathic pain mice and the potential molecular mechanisms involved. Through transcriptome sequencing and bioinformatics analysis combined with in vivo studies, it was identified that esketamine markedly boosts the levels of the m6A methyltransferase METTL3...
Journal of Psychedelic Studies
January 24, 2025
Cecile Giovannetti, Anja Loizaga-Velder, Ricardo Campoy Gomez et al.
5 citations
Abstract Background The Yaqui Intercultural Medicine Clinic was established in 2020 to provide accessible, culturally-attuned treatment for substance use and mental health disorders among an Indigenous Yaqui community in Mexico. The treatment program integrates ayahuasca ceremonies and psychotherapeutic support within a community-based outpatient treatment service. This observational pilot...
JMIR Formative Research
January 24, 2025
Lia Antico, Judson A. Brewer
2 citations
Physician burnout is widespread in health care systems, with harmful consequences on physicians, patients, and health care organizations. Mindfulness training (MT) has proven effective in reducing burnout; however, its time-consuming requirements often pose challenges for physicians who are already struggling with their busy schedules. This study aimed to design a short and pragmatic digital MT...
Pharmaceuticals
January 24, 2025
John E Donello, Roger S McIntyre, Donald B Pickel et al.
14 citations
Plastogens are a class of therapeutics that function by rapidly promoting changes in neuroplasticity. A notable example, ketamine, is receiving great attention due to its combined rapid and long-term antidepressant effects. Ketamine is an N-methyl-D-aspartate receptor (NMDAR) antagonist, and, in addition to its therapeutic activity, it is associated with psychotomimetic and dissociative side...
Journal of Palliative Medicine
January 22, 2025
Roxanne Sholevar, William Kromka, Yvan Beaussant
10 citations
Context: Psychiatric and existential distress are common and difficult-to-treat symptoms that are frequently encountered in the palliative care setting; current treatment options are limited in efficacy and tolerability. Psychedelic-assisted therapies (PAT) have gained public and scientific interest in their potential to induce rapid and effective reductions in psychiatric and existential...
Psychedelic Medicine
January 21, 2025
Maria Helha Fernandes-Nascimento, Karine Viana-Ferreira, André Brooking Negrão
2 citations
Background: Psilocybin is a natural alkaloid with therapeutic potential in the treatment of different mental disorders. Bibliometric information on its use is still scattered in the literature. Objective: To investigate the temporal and bibliometric patterns of publications and the specificity of psilocybin in the treatment of mental disorders. Method: Performed a bibliometric analysis using...
Contemporary Drug Problems
January 19, 2025
Mika Tsupari, Matilda Hellman, T. Tammi
Background The use of psychedelics is on the rise worldwide as more people are experimenting, self-medicating or seeking benefits from these substances. Aims This study explores the use values ascribed to classic psychedelics by 40 users in Finland – a country that scores high in welfare and happiness but has faced an increase in mental health problems and has adapted austerity policies in the...
Pharmaceuticals
January 19, 2025
Marco Bonaso, Letizia Biso, Benedetta Zucchini et al.
13 citations
Psychedelics, historically celebrated for their cultural and spiritual significance, have emerged as potential breakthrough therapeutic agents due to their profound effects on consciousness, emotional processing, mood, and neural plasticity. This review explores the mechanisms underlying psychedelics’ effects, focusing on their ability to modulate brain connectivity and neural circuit activity,...
Psychedelic Intersections
January 17, 2025
Candace Oglesby, Yvan Beaussant
This paper presents insights from the Psychedelic Therapists Diversity (PTD) study, a qualitative study conducted to understand how BIPOC therapists perceive psychedelic therapy and research. The inciting incident for this research occurred during our collaboration on a clinical trial of psilocybin-assisted therapy for depression in cancer patients.1 Candace Oglesby was the only therapist of...