CureusFebruary 19, 2025Paria Parhami, Sydney E Moriarty, Jay Parikh et al.
N, N-dimethyltryptamine (DMT) is a potent hallucinogenic compound with increasing recreational use despite limited safety data. While DMT use has been linked to psychosis, delusional parasitosis as a specific manifestation remains unreported. We present a novel case of a 60-year-old female veteran with chronic post-traumatic stress disorder (PTSD), a history of major depressive disorder, past...
Meditation and mindfulness practices offer promising non-pharmacological alternatives for individuals with spinal cord injury (SCI) to improve their health and well-being, but integrating such practices into daily routines can be challenging. This survey study aims to identify motivators and barriers to engagement with meditation and mindfulness interventions among individuals with SCI. A...
BACKGROUND Mindfulness meditation has demonstrated modest benefits for mental health and well-being, although the relationship between practice dose and outcomes is unclear. Meta-analyses and randomized controlled trials have shown mixed results so far, although such results may stem from methodological issues rather than reflecting the absence of an underlying effect. Research outside...
Irritable bowel syndrome (IBS) is prevalent and can be disabling. Many patients remain symptomatic despite behavioral and medical therapies. Psychedelic-assisted therapy (PAT), in which serotonergic agents like psilocybin are administered in a psychotherapeutic context, has shown promise for refractory psychiatric disorders, including major depressive disorder and post-traumatic stress...
Anhedonia is a core transnosographic symptom in several neuropsychiatric disorders. Recently, the Triple Network (TN) model has been proposed as a useful neurophysiological paradigm for conceptualizing anhedonia, providing new insights to clinicians and researchers. Despite this, the relationship between the functional dynamics of TN and the severity of anhedonia has been relatively...
Internalizing problems, such as worrying, anxiety and low mood, are increasingly common in youth and may constitute an early stage of mental illness development. There is thus an urgent need for effective measures to address mental health complaints as they develop and to prevent progression into more serious mental illness. Enhanced understanding of early-stage mental illness development,...
Financial constraints usually hinder students, especially those in low-middle income countries, from seeking mental health interventions. Hence, it is necessary to identify effective, affordable and sustainable counter-stress measures for college students in low-middle income countries context. This study examines the effect of Mindfulness-Based Stress Reduction (MBSR) on psychological outcomes...
Integrating advanced pharmaceutical innovations and artificial intelligence (AI) offers transformative potential for psychiatric care. This Patent Highlight reviews novel therapeutic strategies, including the synergistic use of monoamine antidepressants and short-duration psychedelics, alongside AI-driven behavioral efficacy tracking. The combination of selective serotonin reuptake inhibitors...
Abstract Background Recent clinical trials reveal that serotonergic psychedelics, including the prototypical hallucinogen lysergic acid diethylamide (LSD), present a promising potential for treating psychiatric disorders, including treatment-resistant depression. LSD is a potent 5-HT receptors ligand endowed with high affinity for most of all 5-HT subtypes and is regularly used as a valuable...
According to some theories of emotion regulation, dreams could modify negative emotions and ultimately reduce their intensity. We introduce here the idea of cathartic dream, a specific and separate type of emotional dream, which is characterized by a dynamic plot with emotional twists, and where negative emotions are expressed and ultimately decreased. This process would reflect psychological...