Abstract According to L.A. Paul, undergoing an experience is transformative if we learn something we cannot learn without having the experience and if it substantially changes our point of view. While the implications of transformative experiences have primarily been discussed in the context of rational choice, their underlying concept has also proven fruitful in the context of unchosen...
[pt] A ayahuasca é uma infusão psicoativa utilizada como enteógeno há séculos, com pesquisas recentes indicando seu potencial como um tratamento promissor para certos transtornos clínicos. Apesar do crescente corpo de literatura científica sobre seus efeitos, ainda há uma escassez de estudos que investiguem as experiências subjetivas de usuários ingênuos de ayahuasca. O primeiro estudo desta...
Abstract Background and Aims Networks of so-called underground, or illegal, psilocybin mushroom practitioners are popularly known to exist, though few systematic investigations of their practices have been conducted. We sought to uncover the experiences of a hidden community of psilocybin practitioners in order to inform scientific and policy dialogues about safe and effective practices in this...
Introduction Health is a multidimensional phenomenon encompassing physical, mental, and social well-being, all of which are deeply interconnected. The COVID-19 pandemic highlighted the importance of mental and social health, as rates of loneliness, depression, and anxiety surged. Mindfulness practices, such as Shambhavi Mahamudra Kriya (SMK), have gained attention for their potential to enhance...
Hallucinogen-persisting Perception Disorder (HPPD) is a rare condition characterized by the re-experiencing of one or more perceptual symptoms that an individual experienced while intoxicated with a hallucinogenic substance when the individual is sober. While there are several case reports of HPPD in adult patients, there is a scarcity of documented cases in children and adolescents. The...
This article explores the potential of the novel antidepressant dextromethorphan-bupropion in addressing treatment-resistant depression (TRD). Traditional approaches, including selective serotonin reuptake inhibitors and serotonin and norepinephrine reuptake inhibitors, alongside antipsychotic agents, often prove insufficient. Amid a global surge in TRD post-COVID-19, dextromethorphan-bupropion...
ABSTRACT Adverse impacts on children in home isolation during the COVID-19 pandemic have been documented. These impacts include increased loneliness, anxiety, depression, posttraumatic disorder, and heightened risk of psychiatric illness. The present study introduces a proto-theoretical model of stress, psychophysiology, and coping to explain this phenomenon. A focus of the research is on...
Abstract Background Bipolar disorder (BD) is a chronic, debilitating mental condition with consistent prevalence across genders and ethnicities. It's marked by high relapse rates, mood swings, and disruptions in various life aspects. Prior research has highlighted neuropsychological impairments in BD. Aims & Objectives This study investigates the therapeutic effect of dextromethorphan (DM), an...
Abstract Background Serotonergic psychedelics such as psilocybin, lysergic acid diethylamide, and DOI exert a hallucinatory effect through the serotonin 5-HT2A receptor (5-HT2A). Recent studies have revealed that serotonergic psychedelics have therapeutic potential for neuropsychiatric disorders, including major depressive and anxiety-related disorders. Aims & Objectives The involvement of...
Δ9-tetrahydrocannabinol (THC), the chief psychoactive ingredient of cannabis, acts in the brain primarily via cannabinoid CB1 receptors. These receptors are implicated in several forms of synaptic plasticity - depolarization-induced suppression of excitation (DSE), metabotropic suppression of excitation (MSE), long term depression (LTD) and activation-dependent desensitization. Cultured...