Palliative MedicineDecember 18, 2025Rita S. Matos, A. C. Silva, Licínio Rego et al.1 citation
Background: Palliative Care is concerned with relieving suffering and improving the quality of life of patients and their families. Currently, questions arise about how to provide patients with good end-of-life care. There has been increasing interest in the beneficial effects of using psilocybin-assisted therapy in patients with severe chronic illnesses near the end of their lives and who...
Abstract Traumatic brain injury (TBI) can result in chronic functional disability and is associated with persistent psychiatric symptoms, including posttraumatic stress disorder (PTSD), depression, and anxiety. Ibogaine, an oneirogenic alkaloid with unique pharmacological properties, has shown initial promise as a potential treatment for TBI-related sequelae. We previously observed large...
Australia’s reclassification of psilocybin as a Schedule 8 substance for treatment-resistant depression represents a significant shift in psychiatric policy. While this regulatory change positions Australia as a global leader in psychedelic medicine, its implementation has revealed substantial challenges. This article critically examines the regulatory, ethical and operational complexities...
Background: Recent studies have highlighted that mindfulness-based therapies, particularly the Mindfulness-Based Stress Reduction (MBSR) program, can help foster greater awareness and improve the management of stress and chronic pain. Mindfulness is defined as a form of awareness that is intentionally cultivated in the present moment, characterized by an attitude of openness and non-judgment....
The global rise in anxiety and depression disorders has drawn attention to compounds like harmine, a Peganum harmala alkaloid, which induces a pronounced anxiety response. Herbal treatments exhibit the potential to relieve such symptoms with minimal or no side effects. This study aimed to investigate the behavioral, neurobiological, and protective effects of the ethanolic extract of Matricaria...
Introduction:Psilocybin, a classical psychedelic, has shown to produce persistent antidepressant effects, including in patients with treatment-resistant depression. In clinical practice, it is common to coprescribe benzodiazepines (BZDs) alongside antidepressants. However, our preliminary study indicated that preadministration of lorazepam diminished the antidepressant-like efficacy and...
Psychedelic-assisted therapy (PAT) has emerged as a promising and innovative approach to treating a range of mental health disorders, including depression, post-traumatic stress disorder (PTSD), and substance use disorders. Once sidelined due to regulatory bans and social stigma, psychedelics such as psilocybin, 3,4-methylenedioxymethamphetamine (MDMA), lysergic acid diethylamide (LSD), and...
Classical psychedelics, like lysergic acid diethylamide (LSD), N,N-dimethyltryptamine (DMT), and psilocybin, can alter perception, emotion, and cognition, and have shown promise as 're-purposed' treatments for some psychiatric disorders. Recent trials have, e.g., demonstrated rapid and sustained symptom relief in treatment-resistant depression. While promising as a treatment, the...
The current research investigates the efficacy of the Mindfulness Meditation Therapy (MMT) in improving the psychological well-being and the academic performance of higher secondary students in India. Young people often face high academic stress levels that negatively influence cognitive abilities and academic success as they cause anxiety, depression, and stress.
BMC PsychologyDecember 15, 2025Nur Nihal Türkel, Mustafa Cemil Karaduran, Hande Gazey et al.
BACKGROUND: Our perspective on time constitutes a fundamental aspect of psychological functioning, making the assessment of time perspective critically important. This study aimed to examine the validity and reliability of the Turkish version of the 18-item Zimbardo Time Perspective Inventory - Short Form (ZTPI-Short), which includes the "Future Negative" subscale, and to explore the...