The global rise in anxiety and depression disorders has drawn attention to compounds like harmine, a Peganum harmala alkaloid, which induces a pronounced anxiety response. Herbal treatments exhibit the potential to relieve such symptoms with minimal or no side effects. This study aimed to investigate the behavioral, neurobiological, and protective effects of the ethanolic extract of Matricaria...
Our previous results showed that a single oral dose (1 or 20 mg/kg body weight) of the anti-addiction agent ibogaine induced in rats 6 and 24 h after administration glycogenolytic activity in hepatocytes, followed by a mild oxidative stress. In this work, we examined the in vivo effect of the same doses of ibogaine on rat kidney morphology, antioxidant enzyme (superoxide dismutases (SOD1 and...
Ibogaine, administered as a single oral dose (1-25 mg/kg body weight), has been used as an addiction-interrupting agent. Its effects persist for up to 72 h. Ex vivo results showed that ibogaine induced cellular energy consumption and restitution, followed by increased reactive oxygen species production and antioxidant activity. Therefore, the aim of this work was to explore the effect of a...