Research SquareNovember 25, 2025Nai‐kong V. Cheung1 citation
preprint
Abstract Traditional monoaminergic medications often offer limited relief for the physical and cognitive symptoms of post-traumatic stress disorder (PTSD) and complex PTSD. Growing data now point to fast-acting, glutamate-based treatments that boost synaptic plasticity and interrupt fear-conditioned neural circuits. We report four sequential cases of hard-to-treat trauma-spectrum...
To systematically evaluate the effectiveness of mindfulness-based nursing interventions (MBNIs) on psychological health outcomes-including depression, anxiety, and quality of life-as well as resilience and educational empowerment among women with gynecologic cancers. This systematic review and meta-analysis was conducted in accordance with PRISMA 2020 guidelines. Randomized controlled trials...
Informal caregivers of people with dementia experience significant caregiving stress. Mindfulness-based interventions are effective approaches for alleviating caregiving stress. However, traditional mindfulness training is intensive and challenging to attend due to the substantial caregiving responsibilities of this population, leading to issues with program attrition and adherence. To address...
Kanker paru merupakan masalah kesehatan global yang serius yang ditandai dengan tingginya angka kejadian dan kematian. Teori gejala tidak menyenangkan berfokus pada penilaian, pemahaman faktor-faktor yang mempengaruhi, dan pengelolaan gejala tidak menyenangkan yang kompleks dan saling terkait termasuk gejala psikologis seperti stres, kecemasan, dan depresi dengan tujuan untuk meningkatkan...
Third-wave cognitive-behavioral therapies (CBT3) have progressively shifted the focus of psychotherapy from symptom reduction to process-based and transdiagnostic mechanisms of change, emphasizing self-identification as a core dimension. Within this evolution, the Self-Identification Program (SIP) represents a conceptual and clinical advancement particularly relevant to mood disorders, where...
Acute subjective experiences induced by psychedelics have been identified as important mediators of therapeutic outcomes in many studies. Mystical experiences specifically, have been correlated with a range of therapeutic outcomes including reductions in symptoms of depression, anxiety and addiction. This paper assesses acute subjective experiences induced by an encapsulated DMT-harmala...
Medical SciencesNovember 20, 2025Silvia Natoli, Arturo Cuomo, Maurizio Marchesini et al.
Background: Chronic pain affects nearly one in five adults worldwide and remains a major healthcare burden due to its persistence, multidimensional impact, and resistance to conventional therapies. The opioid crisis has further highlighted the urgent need for safer and more effective alternatives. Psilocybin, a serotonergic psychedelic compound, has re-emerged as a potential therapeutic option...
Research SquareNovember 19, 2025Irene Njoka, Jenniffer Donkor, Ruth Gakii et al.
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Abstract Background : Stroke is a leading cause of long-term disability, with survivors often experiencing significant psychological distress, including depression and anxiety, which can impact overall recovery and quality of life. Traditional rehabilitation approaches may not fully address these challenges. Mindfulness-Based Interventions (MBIs) have shown promise in managing psychological...
Post-traumatic stress disorder (PTSD) is a chronic psychological disorder that is induced by traumatic events. The pathophysiological mechanism of PTSD involves complex neurobiological processes. However, the underlying mechanism is not clear, leading to lack of effective therapeutic interventions. Mice were exposed to the electric foot shocks using the contextual fear memory paradigm. A...
Molecular PsychiatryNovember 18, 2025A. Arena, M. R. Rubinstein, A. M. Genaro et al.
Ketamine has emerged as a rapid and sustained treatment for Major Depressive Disorder (MDD) and an alternative for patients who have not responded to traditional therapies. Its effects have been partly attributed to the noncompetitive antagonism of the N-methyl-D-aspartate receptor (NMDAR) in the central nervous system, which enhances neuroplasticity. However, the etiopathology of MDD is...