Open Mind2026Amin Nazmuddin Mohammadi, Christine Wekerle
preprint
Alcohol use disorder (AUD) is a prevalent and chronic psychiatric condition characterized by impaired control over alcohol use, compulsive consumption, and high rates of relapse (Grant et al., 2015; Kurihara, 2023). Despite the availability of pharmacological and psychosocial interventions, treatment outcomes remain suboptimal, with substantial rates of non-response and relapse (Lohoff, 2022;...
The clinical use of psychedelic substances and Psychedelic-Assisted Therapy (PAT) is an area of growing interest that also raises significant social concerns and controversy. Despite existing legal restrictions, empirical research on substances such as psilocybin, mescaline, MDMA, LSD, DMT, and ibogaine has been developing, particularly in the treatment of conditions such as treatment-resistant...
The global burden of chronic diseases and mental health disorders has intensified the need for holistic interventions such as yoga. Isha Yoga, a comprehensive system integrating physical postures, breathwork, and meditation, has demonstrated preliminary benefits in stress reduction and physiological regulation. This systematic review evaluates the effects of Isha Yoga practices on mental and...
There is currently a lack of empirical studies investigating whether specific personality traits moderate the effects of mindfulness-based interventions (MBIs) on distinct adolescent mental health outcomes. This study examined how personality traits from a five-factor model (agreeableness, conscientiousness, emotional stability, extraversion, and openness to experience) moderate the effects of...
With a projected shortage of nearly 200,000 Registered Nurses by 2031, the American Association of Colleges of Nursing (AACN)'s 2020 resolution underscored the urgent need to integrate stress management and resilience in nursing education, yet the application of MBSR interventions remains underexplored despite its documented effectiveness in reducing stress, anxiety, and depression among...
Limited evidence supports treatment for distress in life-threatening illness. Psychedelic-assisted psychotherapy (PAP) may help. Despite music's presence in PAP, sparse accounts of music-related experiences exist. Such research is needed to optimize music's presence within PAP. This qualitative analysis aimed to understand participants' music-related accounts of their PAP experiences within a...
Major depressive disorder (MDD) is a leading cause of disability worldwide, with nearly one-third remaining treatment-resistant. Chronic stress is a major risk factor for MDD, whereas acute stress is adaptive and mediated by hypothalamic-pituitary-adrenal axis activation. Ketamine produces rapid antidepressant effects, partly through mammalian target of rapamycin complex 1 (mTORC1) signalling,...
AbstractMindfulness-based cognitive therapy for children (MBCT-C) is a downward and sideways adaptation of the adult mindfulness-based cognitive therapy (MBCT) program. Downward from adults to children ages 8–13 years and sideways from focus as a treatment for depressive relapse to focus on managing stress and anxiety disorders. Both are structured group psychotherapies that have similar aims...
Chronic tinnitus is often accompanied by considerable psychological burden, including anxiety, depression, and impaired quality of life. Mindfulness-based therapy has attracted growing attention as a potential psychological intervention for tinnitus management. This narrative review examines the current literature on the rationale, clinical application, reported efficacy, limitations, and...
2026Sima Abdi Kazaj, Maedeh Ghanbari, Fataneh Espahbodi et al.
Objective: The objective of this study was to examine the effectiveness of mindfulness-based cognitive therapy in reducing social anxiety and enhancing psychological hardiness among adolescents with depression. Methods and Materials: The present study employed a quasi-experimental design with a pretest–posttest control group. The statistical population consisted of adolescents diagnosed with...