Virtual reality-based mindfulness interventions (VRbMIs) increasingly populate studies as scalable tools for stress and emotion regulation. However, findings across psychological outcomes are heterogeneous, and methodological variation in intervention design, outcome measurement, and reporting practices limits cross-study comparability and cumulative synthesis. A PRISMA (Preferred Reporting...
Introduction: Obsessive-compulsive disorder (OCD) is a chronic condition where many patients remain symptomatic despite first-line treatments such as cognitive behavioural therapy and selective serotonin reuptake inhibitors. This randomised controlled trial evaluated mindfulness-based cognitive therapy (MBCT) efficacy as an augmentation strategy and its impact on brain functional connectivity....
Frontiers in Psychiatry2026S Mudasser Shah, Muhammad Jahangir, Ghada Saleh Alhudaithi et al.
The fascia, a pervasive connective tissue network, has traditionally been studied for its structural and biomechanical roles in the human body. However, emerging evidence suggests that fascia may also play a significant role in the pathophysiology of psychiatric disorders. This review article explores the potential links between fascial dysfunction and mental health conditions such as...
Meditation and spiritual practices have moved from the margins of medical interest into the center of contemporary mental health research, with a rapidly growing body of randomized trials, neuroimaging studies, and systematic reviews. Evidence from programs such as Mindfulness Based Stress Reduction, yoga based interventions, Transcendental Meditation, loving kindness practices, and mantra...
Digital mental health interventions (DMHIs), such as mindfulness-based apps, have become popular mental health resources and can be associated with benefits such as reducing stress, anxiety, and depression. However, there are limited data on the impact of DMHIs on improving mental health outside of controlled research settings, and what factors may facilitate or inhibit such potential impact....
Modern psychotherapy increasingly integrates multimodal and process-based approaches designed to respond to the complexity of contemporary clinical presentations. This paper introduces a three-pillar psychotherapeutic model combining (1) a revised cognitive behavioral foundation, (2) consciousness activation techniques derived from hypnosis, and (3) yoga-inspired postural and interoceptive...
The subacute period following the use of classic psychedelics is often marked by an "afterglow" - a state characterized by elevated mood; enhanced psychological well-being; increased emotional openness toward self, others, and nature; and sometimes a heightened sense of clarity and existential meaning. From a neurobiological perspective, subacute psychedelic states have been associated with...
Dextromethorphan/Buproprion (DXM/BUP) has received breakthrough FDA approval in August 2022 as a rapid-acting antidepressant. DXM/BUP is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist and sigma-1 receptor agonist, with bupropion (BUP), a norepinephrine/dopamine reuptake inhibitor and cytochrome P450 2D6 (CYP2D6) inhibitor. As DXM/BUP moves closer to widespread clinical use for...
Depersonalization (DP) and Derealization (DR) refer to perceptual changes of "as-if-character" where the self (→DP) or the surroundings (→DR) are experienced as unreal. These symptoms are highly prevalent in individuals with mental disorders. If these symptoms persist most of the day for months, the diagnosis of depersonalization-derealization-disorder (DDD) is likely. DDD is a common disorder...
Nightmare Disorder characterized by recurrent dysphoric dreams is strongly associated with major depressive episodes (MDE) and suicidal risk. Imagery rehearsal therapy (IRT) is the standard treatment for nightmares, but its effectiveness in individuals with MDE remain understudied. This study evaluated whether IRT is associated with greater improvement in nightmare symptoms compared to sleep...