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I don’t feel like myself: mapping dissociative symptoms across depression severity in a clinical population

Mary-Anne Kate, Benjamin Dixon, David L. Hegarty, Benjamin Buchanan

Current Psychology October 1, 2026 DOI: 10.1007/s12144-026-10128-2 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Observational cross-sectional study Peer reviewed
Sample size 5,384
Population Australian adults receiving mental health care
Measures Depression Anxiety Stress Scales-21 (DASS-21), Multidimensional Inventory of Dissociation-60 (MID-60)
Topics Depression
Key findings Dissociation correlated strongly with depression severity (r = .50), and people with moderate-or-above depression had fivefold greater odds of clinically significant dissociation than those with normal/mild depression (OR = 5.05). Among clients with moderate-or-above depression, 61.7% scored at or above the MID-60 clinical threshold and 68.8% met a probable MID-60 symptom profile suggestive of a DSM-5-TR dissociative disorder or the dissociative subtype of PTSD. The authors argue these findings support routine screening for dissociation in depression.

Abstract

Abstract: This study examined the relationship between depression and dissociation by assessing how specific dissociative symptoms vary with depression severity in a large Australian clinical sample. A total of 5,384 adults receiving mental health care completed the Depression Anxiety Stress Scales-21 (DASS-21) and the Multidimensional Inventory of Dissociation-60 (MID-60). Analyses included Welch’s one-way ANOVA to assess the effect of depression severity on dissociation, as well as correlation and odds ratio analyses to explore associations between depression and dissociative phenomena. Dissociation was strongly correlated with depression severity ( r = .50, p < .001). Individuals with moderate-or-above depression had fivefold greater odds of clinically significant dissociation than those with normal/mild depression (OR = 5.05, 95% CI [4.45, 5.75]). Among clients with moderate-or-above depression, 61.7% scored at or above the MID-60 clinical threshold and 68.8% met a probable MID-60 symptom profile suggestive of a DSM-5-TR dissociative disorder or the dissociative subtype of PTSD. Among subscales, self-confusion showed the strongest association followed by depersonalization/derealization, flashbacks, severe memory problems, persecutory intrusions, and trance experiences ( r s = 0.39–0.56). These findings highlight the high prevalence and patterns of dissociative symptoms in depression and raise important conceptual questions about their role, whether as intrinsic features of depression, as indicators of a dissociative subtype, or as markers of comorbidity. These possibilities are not mutually exclusive. The results support the clinical utility of routine screening for dissociation in individuals presenting with depression, particularly when symptoms are treatment-resistant, complex, or trauma-related. Greater recognition of dissociative phenomena may lead to more accurate diagnosis and more targeted, effective interventions.

Comparable studies

Other cross-sectional and survey studies on depression, most cited first.

Study Year Design Participants
Psychological flexibility mediates the relations between acute psychedelic effects and subjective decreases in depression and anxiety. International sample of people who reported having used a psychedelic 2020 Cross-sectional survey n = 985
5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) used in a naturalistic group setting is associated with unintended improvements in depression and anxiety. Adults who used 5-MeO-DMT in a group setting with structured procedures 2019 Cross-sectional survey n = 362
Psychological and neuropsychological assessment of regular hoasca users. Regular hoasca users from a U.S. branch of União do Vegetal and matched non-user controls 2016 Cross-sectional study n = 57
Adults who microdose psychedelics report health related motivations and lower levels of anxiety and depression compared to non-microdosers Self-selected microdosers and non-microdosers recruited via a mobile application 2021 Cross-sectional survey n = 8,703
Effects of Naturalistic Psychedelic Use on Depression, Anxiety, and Well-Being: Associations With Patterns of Use, Reported Harms, and Transformative Mental States. Adults with at least one lifetime psychedelic experience 2022 Cross-sectional survey n = 2,510

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