Journal of managed care & specialty pharmacy
September 2026
Bridget Flavin, Gary Small, Charles Dragovich et al.
Treatment-resistant depression (TRD) is a subset of major depressive disorder (MDD) most commonly defined as failure to respond to 2 or more antidepressant regimens despite adequate dose, duration, and adherence to treatment. The burden of TRD impacts individuals, families, and society, with outcomes such as decreased health-related quality of life and increased health care utilization and...
The Brown University Psychopharmacology Update
September 1, 2026
A systematic review and meta‐analysis encompassing 26 ran‐domized controlled trials (RCTs) has concluded that both single and repeated infusions of ketamine significantly improve suicidality and depressive symptoms in patients with a major depressive episode. Most of the serious adverse events that were reported in the included trials were determined to be unrelated to study treatment.
International Journal of Medical Science and Clinical Research Studies
August 31, 2026
Kumkum Saxena, C Shalini
Depression is a major mental health disorder influenced by biological, psychological, and social factors. Family conflict, lack of social support, and loss of purpose can increase vulnerability to depression. Yoga Prana Vidya (YPV) is an integrated complementary healthcare system that combines rhythmic breathing, meditation, physical exercises, forgiveness practices, no-touch energy healing,...
Zenodo (CERN European Organization for Nuclear Research)
August 31, 2026
preprint
Evidence for psilocybin use in chronic depression is limited, primarily focusing on treatment-resistant cases. While promising results have been noted in studies, more targeted and extensive research is needed.
International Journal of Innovative Technologies in Social Science
August 31, 2026
Anna Szeszko, Weronika Maria Czernek, Magdalena Cichorzewska et al.
Psychedelic-assisted therapy has emerged as a prominent area for psychiatric investigation particularly with regards to treatment-resistant depression and Post Traumatic Stress Disorder (PTSD). The purpose of this narrative review was to outline the current body of research regarding psychedelic and psychedelic-like compounds in these two psychiatric conditions highlighting psilocybin-assisted...
Medical Science
August 30, 2026
Julia Rogała, Kinga Polityńska, Dominika Ruszel et al.
Treatment-resistant depression occurs in roughly one-third of individuals diagnosed with depression.Ketamine and esketamine have appeared as innovative antidepressant treatments that target the glutamatergic system and deliver promising therapeutic options for patients unresponsive to conventional monoaminergic antidepressants.This review delivers a complete analysis of the mechanisms of...
Bipolar Disorders
August 30, 2026
Chih‐Cheng Lin, Lien‐chung Wei
OBJECTIVES: To contextualize the real-world findings of repeated intravenous ketamine infusions for treatment-resistant bipolar depression (TRBPD) and identify priorities for safer, more durable clinical implementation. METHODS: We provide a focused commentary on Zhou et al. (2023) and integrate selected evidence concerning inflammatory and metabolic correlates, neurocognitive outcomes, and...
European Archives of Psychiatry and Clinical Neuroscience
August 29, 2026
Esketamine-based treatment, depression-specific metacognitive training, and their combination in treatment-resistant depression: 6-month trajectories of depressive symptoms and rumination in a multicenter observational study.
European Journal of Drug Metabolism and Pharmacokinetics
August 28, 2026
Development of a Physiologically Based Pharmacokinetic/Pharmacodynamic Model of Psilocybin/Psilocin from Psilocybe cubensis (Magic Mushroom) in Treatment-Resistant Depression.
Zenodo (CERN European Organization for Nuclear Research)
August 27, 2026
D. Dilhani Indrachapa
preprint
The rapid development of technical power and globalization in the twenty first century have enabled mankind to enjoy unprecedented material comforts but at the same time have presented him with complex social and psychological problems. Young people are experiencing significant mental health issues, mainly stress and depression, in a very competitive society today. This paper investigates...
European Neuropsychopharmacology
August 27, 2026
correction
Erratum to "Long-term treatment with esketamine nasal spray in patients with treatment resistant depression: Results from the ESCAPE-LTE study" [European Neuropsychopharmacology 107 (2026) 112801].
BMC Anesthesiology
August 26, 2026
Mao Li, Wen Wen, Xiang Wen
Postoperative depression and anxiety are common in elderly patients undergoing joint replacement surgery and may affect recovery. Esketamine has rapid antidepressant effects, but evidence for combined perioperative use remains limited, particularly in elderly patients undergoing joint replacement surgery. This study evaluated the association between combined perioperative esketamine exposure...
Journal of Affective Disorders
August 26, 2026
Decreased accumbens-amygdala connectivity is associated with sleep improvement in late-life depression following mindfulness-based cognitive therapy.
Healthcare
August 26, 2026
Mostafa A. Sayed Ali, Palanisamy Amirthalingam, Hanan Alshareef et al.
Background/Objectives: This study evaluated the real-world effectiveness and safety of intranasal esketamine plus oral antidepressants compared with venlafaxine-based oral antidepressant therapy in adults with moderate-to-severe treatment-resistant depression (TRD). Methods: This retrospective cohort study used electronic medical records from a mental health hospital between January 2023 and...
Women & health
August 25, 2026
Adebimpe Obembe, Jasmine Ramos, Emily Reis et al.
Premenstrual syndrome (PMS) affects many women of reproductive age, often disrupting daily activities. Mindfulness- and relaxation-based techniques, such as yoga and progressive muscle relaxation techniques, can alleviate both physical and psychosocial symptoms associated with PMS. This systematic review synthesized existing evidence on the effects of mindfulness and relaxation interventions on...
Neuropsychiatrie
August 25, 2026
Nicolas Schmelzle, Katrin Neubacher, Paul L. Plener et al.
BACKGROUND: Depressive symptoms and suicidality are highly prevalent in adolescents with early-onset psychosis (EOP) and often remain refractory to standard treatment. While S‑ketamine is an established treatment for treatment-resistant depression in adults (TRD), its use in primary psychotic disorders remains scarce due to risk of exacerbation of psychotic symptoms. CASE PRESENTATION: We...
Biomolecules
August 24, 2026
Agnieszka Pałucha-Poniewiera
The use of animal models to study mental illnesses, such as depression, requires proper standardization and extensive expertise. Achieving good construct, face, and predictive validity in depression models is quite challenging. Currently, only a few environmental models, mostly based on chronic stress, and a limited number of genetic models fulfill these criteria. In the quest for new...
JMIR mHealth and uHealth
August 21, 2026
Houlin Hong, Matthew R Lootens, Rebecca Bachman et al.
Background: Young adults experience disproportionately high levels of stress, creating significant health challenges. This demographic often underuses traditional stress management methods due to perceived ineffectiveness, inconvenience, or stigma. Given these challenges, mobile virtual reality (VR) offers a novel, engaging, and accessible alternative stress management tool that may be more...
Frontiers in Nutrition
August 21, 2026
Agnieszka Mechlińska, Mariusz S. Wiglusz, Jakub Słupski et al.
This study evaluated the acute and short-term effects of repeated ketamine treatment on appetite in adult inpatients with treatment-resistant mood disorders, including major depressive disorder and bipolar disorder. Appetite, hunger, and desire to eat were assessed using the Visual Analog Scales (VAS) and the Simplified Nutritional Appetite Questionnaire (SNAQ) at baseline and at multiple time...
World Journal of Psychiatry
August 19, 2026
Yun-Xia Shi, Bing Qin, Xiao-Xiao Wang et al.
BACKGROUND Lower extremity arteriosclerotic occlusive disease (LEAOD) is a prevalent chronic vascular condition that significantly increases the risk of lower limb dysfunction and depressive symptoms. Mindfulness-based interventions have demonstrated efficacy in improving mood and coping ability in patients with various chronic illnesses; however, their specific impact on the dual burden of...