Prescription opioid misuse among chronic pain patients is undergirded by self-regulatory deficits, affective distress, and opioid-cue reactivity. Dispositional mindfulness has been associated with enhanced self-regulation, lower distress, and adaptive autonomic responses following drug-cue exposure. We hypothesized that dispositional mindfulness might serve as a protective factor among...
JMIR Mental HealthSeptember 25, 2018Julia Sevilla-Llewellyn-Jones, Olga Santesteban-Echarri, Ingrid Pryor et al.
Web-based mindfulness interventions are increasingly delivered through the internet to treat mental health conditions. The objective of this study was to determine the effectiveness of web-based mindfulness interventions in clinical mental health populations. Secondary aims were to explore the impact of study variables on the effectiveness of web-based mindfulness interventions. We performed a...
BACKGROUND: Ketamine has been demonstrated to improve depressive symptoms.AimsEvaluation of efficacy, safety and feasibility of repeated oral ketamine for out-patients with treatment-resistant depression (TRD). METHOD: In a randomised, double-blind, placebo-controlled, proof-of-concept trial, 41 participants received either 1 mg/kg oral ketamine or placebo thrice weekly for 21 days...
In this review, we will discuss the safety of repeated treatments with ketamine for patients with treatment-resistant depression (TRD), a condition in which patients with major depression do not show any clinical improvements following treatments with at least two antidepressant drugs. We will discuss the effects of these treatments in both sexes at different developmental periods. Numerous...
Neural plasticity-the ability to change and adapt in response to stimuli-is an essential aspect of healthy brain function and, in principle, can be harnessed to promote recovery from a wide variety of brain disorders. Many neuropsychiatric diseases including mood, anxiety, and substance use disorders arise from an inability to weaken and/or strengthen pathologic and beneficial circuits,...
Background: Comorbidity of anxiety and mood disorders is rather common, making the treatment of each disorder more difficult. Posttraumatic stress disorder (PTSD) is one of the anxiety disorders with a high degree of association with depression; PTSD-depression comorbidity can significantly affect the quality of life of the ones affected. Hence, using the best way to deal with each of these...
tial impact of psychedelic drugs on psychiatry to that of the microscope on biology and, while this analogy may strike some as laughable, let us reflect for a moment that human research with psychedelics has been effectively moribund since the restrictive drug policy reforms of the 1960s-70s, and has only recently been revived. Classic serotonergic psychedelics – such as LSD, psilocybin and...
NeuropsychopharmacologySeptember 6, 2018Haley L Goodwill, Gabriela Manzano-Nieves, Meghan Gallo et al.
Childhood trauma and neglect influence emotional development and increase the risk for and severity of mental illness. Women have a heightened susceptibility to the effects of early life stress (ELS) and are twice as likely as men to develop debilitating, stress-associated disorders later in life, such as major depressive disorder (MDD). Until now, mouse models of depression have been largely...
Pregnant women tend to experience depression during pregnancy. This can affect mothers and babies’ health widely. Previous research has found that mindfulness and self-compassion can reduce depression in pregnant women in abroad, but it still no specific research on it in Indonesia. Therefore, the purpose of this study was to see the relationship and also the role of mindfulness and...
Low Agreeableness is a personality dimension involving hostility, antagonistic behaviors, and the propensity for conflict. Within the repertoire of positive psychology interventions, the practice of compassion may be a particularly redemptive for these individuals given their deficits in this domain. Helping has previously been found to boosts momentary positive affect in nonaltruists (Conway,...
Background: Considering the increasing prevalence of psychological problems, complications, and consequences of depression in patients undergoing hemodialysis (HD), the application of complementary therapies such as meditation counseling is highly important. Objectives: Therefore, this study aimed to investigate the effect of meditation on depression in patients undergoing HD. Methods: This...
We conducted a 26-month follow-up of a previously reported 12-month study that compared mindfulness-based cognitive therapy (MBCT) to a rigorous active control condition (ACC) for depressive relapse/recurrence prevention and improvements in depressive symptoms and life satisfaction. Participants in remission from major depression were randomized to an 8-week MBCT group (n = 46) or the ACC (n =...
Purpose: The incidence of subthreshold depression (StD) in adolescents is growing rapidly, which in turn is known to impair functioning and increase the risk of major depression. It is therefore important to provide effective intervention to prevent the transition from StD to major depression. As a traditional Chinese mind-body exercise, Tai Chi Chuan (TCC) may be an available selection....
NeuropharmacologySeptember 1, 2018Dylan Chou, Hsien-Yu Peng, Tzer-Bin Lin et al.
It has been widely reported that ketamine rescues chronic stress-induced depression-like behavior, but the underlying cellular mechanisms of the rapid antidepressant actions of ketamine remain largely unclear. Both male and female Sprague-Dawley rats were used and received modified learned helplessness paradigm to induce depression-like behavior. Depression-like behavior was assayed and...
Depression is one of the most debilitating neuropsychiatric disorders. Most of the current antidepressants have long remission time and low recovery rate. This study explores the impact of ketamine on neuronal and astroglial metabolic activity in prefrontal cortex in a social defeat (SD) model of depression. C57BL/6 mice were subjected to a social defeat paradigm for 5 min a day for 10...
Novel interventions for treatment-resistant depression (TRD) in adolescents are urgently needed. Ketamine has been studied in adults with TRD, but little information is available for adolescents. This study investigated efficacy and tolerability of intravenous ketamine in adolescents with TRD, and explored clinical response predictors. Adolescents, 12-18 years of age, with TRD (failure to...
The authors report about a clinical study conducted to evaluate the efficacy of Biotransenergetica, a transpersonal psychotherapy approach, in a general practitioner office. In addiction to prove the efficacy of Biotransenergetica this study demonstrates that there is no ostracism or rejection when research is conducted with rigorous methods. (This study will be published as a full article in...
Electroconvulsive therapy (ECT) is one of the most effective treatments for depressive disorder. Sub-anesthetic dose of ketamine exerts a rapid and robust antidepressive effect. However, it is still unclear whether ketamine usage in ECT is efficacious as an antidepressant. We aimed to conduct a systematic review and meta-analysis on the effects of ketamine in ECT among patients with depressive...
INTRODUCTION: The use of ketamine as an option in the treatment of depressive disorder is growing rapidly, supported by numerous clinical trials attesting its efficacy and safety. Esketamine, the S (+) enantiomer of ketamine, is the most widely used form in the anesthetic environment in some countries, and new studies have shown that it may also be effective in depression and with better...
Journal of Ayurvedic and Herbal MedicineAugust 31, 2018B. Sivaramappa, Sudheer Deshpande, Joint Director Vyasa Eknath Bhavan Bangalore Karnataka India et al.3 citations
Aim: To study the effect of Anpanasati Meditation on individuals with moderate depression. Methods: A total of 115 participants who were willing to participate in the study were recruited for the study. Anapanasati meditation was used as an intervention. The participants were divided into two groups experiment and control groups. Experiment group had 59 persons performing Anapanasati meditation...