Research published in Neurobiology of Stress

Default mode network connectivity contributes the augment effect stress recovery by natural viewing

Neurobiology of Stress September 12, 2025 Zi-Ni Chen, Chanyu Wang, T. Toulopoulou et al.

The psychological benefits of exposure to natural environments are well established. However, whether simply viewing nature images produce similar restorative effects and the brain mechanisms involved remain unclear. For study purposes, we recruited 131 healthy university students and randomly assigned them to a nature image viewing group (NG) or a city image viewing group (CG), with 49...

DOI: 10.1016/j.ynstr.2025.100759 Full text

Can the gut-brain axis provide insight into psilocybin's therapeutic value in reducing stress?

Neurobiology of Stress May 1, 2025 Alanna Kit, Kate Conway, Savannah Makarowski et al. 5 citations

There is growing interest in exploring the therapeutic potential and mechanisms of action of psilocybin on stress-related neuropsychiatric disorders, including depression, generalized anxiety disorder (GAD), post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), addiction, and disordered eating. Despite promising progressions in preclinical and clinical research, the...

DOI: 10.1016/j.ynstr.2025.100732 5-HT Psilocybin Inflammation Neuropsychiatric disorders +7

HCN channel inhibitor induces ketamine-like rapid and sustained antidepressant effects in chronic social defeat stress model

Neurobiology of Stress August 1, 2023 Min Cai, Yingbo Zhu, M. R. Shanley et al.

Repeated, long-term (weeks to months) exposure to standard antidepressant medications is required to achieve treatment efficacy. In contrast, acute ketamine quickly improves mood for an extended time. Recent work implicates that hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are involved in mediating ketamine's antidepressant effects. In this study, we directly targeted HCN...

DOI: 10.1016/j.ynstr.2023.100565 Full text

Effects of stress on endophenotypes of suicide across species: A role for ketamine in risk mitigation

Neurobiology of Stress April 20, 2022 Steven J. Lamontagne, Elizabeth D. Ballard, Carlos A. Zarate 8 citations

Suicide is a leading cause of death and morbidity worldwide, yet few interventions are available to mitigate its risk. Barriers to effective treatments involve a limited understanding of factors that predict the onset of suicidal thoughts and behaviors. In the context of suicide risk, stress is a precipitating factor that is largely overlooked in the literature. Indeed, the pathophysiology of...

DOI: 10.1016/j.ynstr.2022.100450

Low-dose S-ketamine exerts antidepressant-like effects via enhanced hippocampal synaptic plasticity in postpartum depression rats.

Neurobiology of Stress 2022 Zhuoyu Ren, Mingling Wang, Mokhtar Aldhabi et al. 28 citations

Rapid antidepressant effects of S-ketamine have repeatedly been confirmed in patients with depression, as well as in chronic unpredictable mild stress (CUMS) animal models. However, the pharmacological study of S-ketamine for anti-postpartum depression has not been considered. In this study, the classical method of reproductive hormone withdrawal was used to construct a rat model of postpartum...

DOI: 10.1016/j.ynstr.2021.100422 Full text S-ketamine Synaptic plasticity Electrophysiology Hippocampi +1

On the safety of repeated ketamine infusions for the treatment of depression: Effects of sex and developmental periods

Neurobiology of Stress September 21, 2018 Caroline E. Strong, Mohamed Kabbaj 60 citations

In this review, we will discuss the safety of repeated treatments with ketamine for patients with treatment-resistant depression (TRD), a condition in which patients with major depression do not show any clinical improvements following treatments with at least two antidepressant drugs. We will discuss the effects of these treatments in both sexes at different developmental periods. Numerous...

DOI: 10.1016/j.ynstr.2018.09.001