From psychache to neuroplasticity: A unified rescue-repair model of Ketamine's anti-suicidal action.
Neurosci Biobehav Rev June 7, 2026 Yoav Domany, Aviv Solomon-Shashua
Suicide, the individual desire to take one's own life, at whose core lies the unbearable psychological pain Shneidman called psychache, is a uniquely human experience. Unlike depression, suicidality has no preclinical analog. Suicidality and chronic depression, long treated as a single clinical entity, are increasingly recognized as partly separable in neurobiology and treatment response....