Cochrane Database of Systematic Reviews
January 19, 2026
Gülay Ateş, Patrick Welsch, Petra Klose et al.
5 citations
Estimates of the population prevalence of chronic pain with neuropathic components range from 6% to 10%. Current pharmacological treatments for neuropathic pain help only a minority. New treatments are needed. Cannabis is increasingly promoted in the media as a treatment for chronic pain. This is an update of a review first published in 2018. To assess the benefits and harms of cannabis-based...
Cochrane Database of Systematic Reviews
September 11, 2024
Sivan Schipper, Kabir Nigam, Yasmin Schmid et al.
34 citations
Implications for practice Psychedelic-assisted therapy with classical psychedelics (psilocybin, LSD) may be effective for treating anxiety, depression, and possibly existential distress, in people facing a life-threatening disease. Psychedelic-assisted therapy seemed to be well tolerated, with no treatment-emergent serious adverse events reported in the studies included in this review. However,...
Cochrane Database of Systematic Reviews
February 15, 2024
Karen Rees, Andrea Takeda, Rachel Court et al.
15 citations
Interventions incorporating meditation to address stress, anxiety, and depression, and improve self-management, are becoming popular for many health conditions. Stress is a risk factor for cardiovascular disease (CVD) and clusters with other modifiable behavioural risk factors, such as smoking. Meditation may therefore be a useful CVD prevention strategy. To determine the effectiveness of...
Cochrane Database of Systematic Reviews
November 21, 2022
Sivan Schipper, Kabir Nigam, Vanessa Piechotta et al.
4 citations
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of psychedelic/entactogen‐assisted therapy compared to placebo or active comparators (e.g. antidepressants) for treatment of anxiety, depression, and existential distress in adult palliative care.
Cochrane Database of Systematic Reviews
December 10, 2021
Praba Sekhar, Qiao Xin Tee, Gizem Ashraf et al.
Background: Mindfulness interventions are increasingly popular as an approach to improve mental well-being. To date, no Cochrane Review examines the effectiveness of mindfulness in medical students and junior doctors. Thus, questions remain regarding the efficacy of mindfulness interventions as a preventative mechanism in this population, which is at high risk for poor mental health....
Cochrane Database of Systematic Reviews
October 20, 2021
Simon B. Goldberg, Brian Pace, Matas Griskaitis et al.
Background: Substance use disorders (SUDs) are highly prevalent and associated with a substantial public health burden. Although evidence-based interventions exist for treating SUDs, many individuals remain symptomatic despite treatment, and relapse is common.Mindfulness-based interventions (MBIs) have been examined for the treatment of SUDs, but available evidence is mixed. Objectives: To...
Cochrane Database of Systematic Reviews
October 8, 2021
Rebecca L. Dean, Tahnee Marquardt, Claudia C. Hurducas et al.
41 citations
BACKGROUND Glutamergic system dysfunction has been implicated in the pathophysiology of bipolar depression. This is an update of the 2015 Cochrane Review for the use of glutamate receptor modulators for depression in bipolar disorder. OBJECTIVES 1. To assess the effects of ketamine and other glutamate receptor modulators in alleviating the acute symptoms of depression in people with bipolar...
Cochrane Database of Systematic Reviews
September 12, 2021
Rebecca L. Dean, Claudia C. Hurducas, Keith Hawton et al.
97 citations
BACKGROUND Many studies have recently been conducted to assess the antidepressant efficacy of glutamate modification in mood disorders. This is an update of a review first published in 2015 focusing on the use of glutamate receptor modulators in unipolar depression. OBJECTIVES To assess the effects - and review the acceptability and tolerability - of ketamine and other glutamate receptor...
Cochrane Database of Systematic Reviews
August 14, 2018
Zheng Liu, Yuying Sun, Bao‐Liang Zhong
60 citations
BACKGROUND: Caring for people with dementia is highly challenging, and family carers are recognised as being at increased risk of physical and mental ill-health. Most current interventions have limited success in reducing stress among carers of people with dementia. Mindfulness-based stress reduction (MBSR) draws on a range of practices and may be a promising approach to helping carers of...
Cochrane Database of Systematic Reviews
November 15, 2017
Louise Hartley, Angelique Mavrodaris, Nadine Flowers et al.
A major determinant in cardiovascular disease (CVD) is stress. As transcendental meditation (TM) is thought to help in lowering negative stress indicators, it may be a beneficial strategy for the primary prevention of CVD. To determine the effectiveness of TM for the primary prevention of CVD. We searched the following electronic databases: the Cochrane Central Register of Controlled Trials...
Cochrane Database of Systematic Reviews
June 28, 2017
Rae Frances Bell, Christopher Eccleston, Eija Kalso
246 citations
BACKGROUND: This is an update of a review first published in 2003 and updated in 2012.Ketamine is a commonly used anaesthetic agent, and in subanaesthetic doses is also given as an adjuvant to opioids for the treatment of refractory cancer pain, when opioids alone or in combination with appropriate adjuvant analgesics prove to be ineffective. Ketamine is known to have psychomimetic (including...
Cochrane Database of Systematic Reviews
February 3, 2016
Ines Salhofer, Andrea Will, Ina Monsef et al.
22 citations
BACKGROUND: Malignant neoplasms of the lymphoid or myeloid cell lines including lymphoma, leukaemia and myeloma are referred to as haematological malignancies. Complementary and alternative treatment options such as meditation practice or yoga are becoming popular by treating all aspects of the disease including physical and psychological symptoms. However, there is still unclear evidence about...
Cochrane Database of Systematic Reviews
October 14, 2014
Benjamin C McLoughlin, Jonathan A Pushpa-Rajah, Donna Gillies et al.
Schizophrenia is a mental illness causing disordered beliefs, ideas and sensations. Many people with schizophrenia smoke cannabis, and it is unclear why a large proportion do so and if the effects are harmful or beneficial. It is also unclear what the best method is to allow people with schizophrenia to alter their cannabis intake. To assess the effects of specific psychological treatments for...
Cochrane Database of Systematic Reviews
September 8, 2010
R. Churchill, T. Moore, P. Davies et al.
This is the protocol for a review and there is no abstract. The objectives are as follows: To examine the effectiveness and acceptability of all third wave CBT approaches compared with treatment as usual/waiting list/attention placebo control conditions for acute depression. To examine the effectiveness and acceptability of different third wave CBT approaches (ACT, compassionate mind training,...
Cochrane Database of Systematic Reviews
September 1, 2010
Mindfulness-based 'third wave' cognitive and behavioural therapies versus other psychological therapies for depression.
Cochrane Database of Systematic Reviews
June 16, 2010
Thawatchai Krisanaprakornkit, Chetta Ngamjarus, Chartree Witoonchart et al.
Attention-deficit/hyperactivity disorder (ADHD) is one of the most common developmental disorders experienced in childhood and can persist into adulthood. The disorder has early onset and is characterized by a combination of overactive, poorly modulated behavior with marked inattention. In the long term it can impair academic performance, vocational success and social-emotional development....
Cochrane Database of Systematic Reviews
April 18, 2007
M A Gillman, F J Lichtigfeld, T N Young
Alcoholism is a global problem with 5-10% of the world's population demonstrating alcohol-related diseases. One of the most severe consequences of alcohol dependence is the withdrawal syndrome, for which benzodiazepines are the most popular current treatment. An alternative method to benzodiazepine employs psychotropic analgesic nitrous oxide (PAN). To assess the effects of PAN for treating...
Cochrane Database of Systematic Reviews
January 25, 2006
Thawatchai Krisanaprakornkit, W Krisanaprakornkit, Nawanant Piyavhatkul et al.
Anxiety disorders are characterised by long term worry, tension, nervousness, fidgeting and symptoms of autonomic system hyperactivity. Meditation is an age-old self regulatory strategy which is gaining more interest in mental health and psychiatry. Meditation can reduce arousal state and may ameliorate anxiety symptoms in various anxiety conditions. To investigate the effectiveness of...