Frontiers in Physiology
August 10, 2026
Dan Yu, Ye Liao, Jie Li et al.
Propofol, one of the most widely used intravenous anesthetics, is undergoing a transformative identity shift from a purely surgical agent to a potential therapeutic tool for neuropsychiatric disorders. This review synthesizes current evidence on the emerging field of propofol therapeutics, with a focus on its rapid antidepressant, anti-anhedonia, and anxiolytic effects. We first examine...
Asclepius International Journal of Scientific Health Science
August 7, 2026
Arthur Gomes Ferreira
A dependência da nicotina representa um dos principais desafios da saúde pública mundial, sendo responsável por elevadas taxas de morbimortalidade e associada ao desenvolvimento de doenças cardiovasculares, respiratórias e neoplásicas. Embora existam diferentes estratégias terapêuticas para a cessação do tabagismo, as elevadas taxas de recaída evidenciam a necessidade de novas abordagens...
International Journal of Research Publication and Reviews
August 6, 2026
Nguyen Thi Nhien Trang, Le Hong Linh
In recent years, mindfulness meditation has gained significant attention as a tool for better emotional control and mental health. This conceptual article brings together different studies to show what fundamental processes cause its psychological benefits. By referring to well-known emotion regulation models like Gross's Process Model, Monitor and Acceptance Theory (MAT), and Mindfulness to...
Zenodo (CERN European Organization for Nuclear Research)
August 6, 2026
Narayan Rout
preprint
This article examines the neuroscientific evidence for states corresponding to Samadhi as described in the Yoga Sutras of Patanjali and Advaita Vedanta (Turiya, the fourth state). Seven confirmed neuroscientific findings: (1) Default mode network (DMN) deactivation in deep meditators — Judson Brewer (Brown University) and colleagues: experienced meditators show dramatic DMN suppression...
BMC Psychiatry
August 5, 2026
Xiang Liu, Yuanzhi He, Lifeng Li et al.
Abstract Introduction Major depressive disorder (MDD) is characterized by dysfunction in higher-order cortical regions involved in emotional and cognitive processes; however, its neurobiological basis remains unclear. Pharmacological treatments, including esketamine and sertraline, produce rapid antidepressant effects. We investigated the local intrinsic neural dynamics underlying these...
Molecular Psychiatry
August 4, 2026
Kim P. C. Kuypers, Natasha L. Mason, Aurelie Carlier et al.
Women experience a disproportionate burden of affective and stress-related disorders, with symptom variability shaped by endocrine transitions across the menstrual cycle, pregnancy, postpartum, and menopause. Although psychedelic-assisted therapies are increasingly investigated for these conditions, hormonal state represents a largely unaccounted determinant of variability in exposure,...
Progress in Neuro-Psychopharmacology and Biological Psychiatry
August 1, 2026
Christian N. Schmitz, Marijan Bernardic, Anamaria-Domnica Vlădoiu et al.
High ventilation breathwork (HVB) is increasingly used in psychotherapeutic and contemplative contexts to induce altered states of consciousness (ASC), yet its neurobiological mechanisms remain poorly understood. Thirty experienced HVB practitioners (mean age 44.97 ± 11.80 years) underwent perfusion and resting-state fMRI to assess acute cerebrovascular and post-acute network changes. Cerebral...
STUDIES IN HEALTH SCIENCES
July 27, 2026
Kleber Mirallia de Oliveira, Yohana Heloise Mirallia, A. C. Moreira et al.
Background: The practice of meditation and mindfulness techniques has garnered significant interest within the international scientific community due to its potential to induce functional and structural plasticity in the Central Nervous System (CNS). This advanced narrative review aims to analyze, refine, and systematize the neuroscientific foundations of meditation, correlating ultrastructural...
Nature Neuroscience
July 20, 2026
Zhi-Peng Yu, Zhong-Yu Zhang, Qiong Li et al.
Psychedelics, known for prosocial effects and therapeutic potential in psychiatry, are often first used during adolescence, yet their enduring impact on social behavior and its underlying circuits remain unclear. Here we show that repeated exposure to the serotonergic psychedelic drug 25C-NBOMe during adolescence, but not exposure in adulthood, induced lasting competitive avoidance in male...
Neuropsychopharmacology
July 20, 2026
Noam Goldway, Itamar Jalon, Yara Agbaria et al.
Abstract Ketamine produces both analgesic and dissociative effects, but whether analgesia depends on dissociation remains debated. This question is part of a broader discussion on whether the subjective experiences elicited by psychoactive drugs are necessary for their therapeutic benefits. Here, we tested whether ketamine-induced analgesia and dissociation show separable behavioral and neural...