Psychiatry and Clinical Neurosciences
August 29, 2026
Xuhan Cui, Leyi Zhang, Y. Ou et al.
AIM Pathological dissociation is a complex clinical symptom widely observed across various psychiatric disorders. Dissociative symptoms prolong the duration of hospitalization and are associated with a poor clinical prognosis. Although several pathological models (e.g., the frontal-limbic overmodulation model and the defense cascade model) have been proposed to interpret dissociative symptoms,...
Zenodo (CERN European Organization for Nuclear Research)
August 28, 2026
Jonghoon Lee
preprint
Psychoanalytic and phenomenological accounts of anxiety distinguish between raw bodily disquiet and top-down symbolic structures—morality, faith, and meaning—that subjects erect to contain it. We propose a neuropsychoanalytic model mapping this distinction onto two interacting neural registers: a bottom-up interoceptive circuit centered on the anterior insula and Salience Network (SN), and a...
Nursing Edição Brasileira
August 27, 2026
Ana Júlia Costa Matias Gomes, Jéssica Camilo Ramos Rodrigues, Valber Pinheiro Padilha Filho
Os psicodélicos clássicos, como a psilocibina, o LSD e a DMT, têm despertado crescente interesse na psiquiatria moderna devido ao seu potencial terapêutico em transtornos resistentes ao tratamento. O mecanismo de ação primário dessas substâncias envolve o agonismo dos receptores de serotonina 5-HT2A, localizados principalmente no córtex pré-frontal. Esta revisão sistemática analisou como a...
Journal of Integrative Neuroscience
August 26, 2026
Martin Pham, Sonia Odutola, Hrishikesh Pable et al.
The triple network model has become a widely adopted framework for studying large-scale brain organization in basic and clinical neuroscience; however, accumulating evidence complicates this taxonomy. The default mode network, once labelled "task-negative", is now recognized as dynamically engaged across both internally directed and task-related processes. The salience network, often described...
medRxiv
August 22, 2026
Tobias P. Whelan, Mihail Dimitrov, Lucas G. S. França et al.
preprint
Importance There is increasing interest in the potential of psilocybin to treat mental health and neurodevelopmental conditions. At high doses, the therapeutic benefit of psilocybin is linked to greater functional connectivity or integration between large-scale brain networks which underpin mood, emotion and cognition. However, it is unknown how the brain responds to psilocybin in autism - a...
Tomography
August 18, 2026
Faten M. Aldhafeeri
Background/Objectives: Auditory verbal hallucinations (AVH) are clinically heterogeneous experiences that may occur across psychiatric, neurological, sensory, and non-clinical contexts. This controlled pilot study investigated multimodal structural and functional MRI features associated with persistent AVH in a psychiatric clinical population, recruited from outpatient psychiatric clinics and...
Translational Psychiatry
August 18, 2026
Marvin Sören Meiering, David Weigner, Matti Gärtner et al.
Rumination has been associated with aberrant dynamics of a coactivation pattern (CAP) comprising the default mode (DMN) and frontoparietal (FPN) networks. Ketamine exerts rapid antidepressant effects and may influence these dynamics via glutamatergic mechanisms. In a randomized, double-blind, placebo-controlled fMRI study, we investigated ketamine's effects on dynamic CAPs associated with...
International Journal of Philosophy and Theology
August 13, 2026
Hsin-Yuan Liu, Hsuan-Pin Chen
1 citation
This paper addresses the contemporary crisis of existential vacuum by examining how death anxiety may be reinterpreted through meaning-centered contemplation. Drawing on Ken Wilber’s Three Eyes of Knowing, the study brings Viktor Frankl’s logotherapy, transpersonal psychology, Buddhist Nianfo practice, and selected insights from cognitive neuroscience into philosophical dialogue. Nianfo is...
Revista de Psicopatología y Psicología Clínica
August 12, 2026
Luis de Rivera, Estefanía Hernández‐Martín, Leonor de Rivera-Monterrey et al.
ABSTRACTObjective: Autogenic Training (AT) is a well-established psychophysiological method used in medicine and clinical psychology for stress reduction and emotional regulation. Traditionally viewed as a relaxation technique, it is now considered a form of meditation, with a unique “Dual Concentration” technique, which combines passive interoceptive focus with specific mental verbalizations....
bioRxiv (Cold Spring Harbor Laboratory)
August 12, 2026
Orr Shahar, Alexander Botvinnik, Masha Chaykin et al.
preprint
Abstract N, N-dimethyltryptamine (DMT) and 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT) are structurally related tryptamine psychedelics with emerging therapeutic potential, yet their comparative acute pharmacology and longer-term neuroplastic effects remain incompletely defined. Here we show that DMT produces a bell-shaped dose–response curve in the mouse head-twitch response (HTR) assay,...