Jie Li

Multi-scale effects of single-dose psilocybin in the macaque brain

Research Square October 29, 2026 Jiaojian Wang, Jin Chen, Wenjie Sun et al. preprint

Abstract Psilocybin holds strong therapeutic promise for treating major depressive disorder. However, the cellular and molecular substrates underlying its action have not been fully elucidated, especially in the primate brain. We combined multimodal MRI, magnetic resonance spectroscopy (MRS), cerebrospinal fluid (CSF) proteomics and metabolomics, and single-nucleus RNA sequencing (snRNA-seq) to...

DOI: 10.21203/rs.3.rs-11081511/v1 (opens in new tab) Full text (opens in new tab)

Propofol for depression: mechanisms and therapeutic potential

Frontiers in Physiology August 10, 2026 Dan Yu, Ye Liao, Jie Li et al.

Propofol, one of the most widely used intravenous anesthetics, is undergoing a transformative identity shift from a purely surgical agent to a potential therapeutic tool for neuropsychiatric disorders. This review synthesizes current evidence on the emerging field of propofol therapeutics, with a focus on its rapid antidepressant, anti-anhedonia, and anxiolytic effects. We first examine...

DOI: 10.3389/fphys.2026.1876988 (opens in new tab)

Effects of mindfulness-based interventions on cognitive impairment in patients with cancer: A systematic review and meta-analysis.

International journal of clinical and health psychology : IJCHP 2025 Shuqin Jiang, Yaoyao Sun, Lixiang Yu et al. 9 citations

Cognitive impairment has been widely reported among cancer survivors, significantly impacting their quality of life. Mindfulness interventions are increasingly used to alleviate cognitive impairment in patients with cancer. This study aimed to assess the effects of mindfulness interventions on cognitive impairment in patients with cancer post-intervention and at follow-up. Up until February...

DOI: 10.1016/j.ijchp.2025.100576 (opens in new tab) Full text (opens in new tab) Cognitive impairment Meta-analysis Mindfulness interventions Quality of life +8

Traditional Chinese Manual Therapy (Tuina) reshape the function of default mode network in patients with lumbar disc herniation.

Frontiers in Neuroscience March 15, 2023 Xiao-Min Chen, Ya Wen, Shao Chen et al.

Purpose: Investigating the changes of regional homogeneity (ReHo) values and both static and dynamic functional connectivity (FC) before and after Traditional Chinese Manual Therapy (Tuina) in patients with lumbar disk herniation (LDH) through resting-state functional magnetic resonance imaging (RS-fMRI). Based on this, we observe the effect of Tuina on the above abnormal changes. Methods:...

DOI: 10.3389/fnins.2023.1125677 (opens in new tab) Full text (opens in new tab) Lumbar disc herniation Tuina Functional connectivity Resting-State FMRI +1

Ketamine plus propofol-electroconvulsive therapy (ECT) transiently improves the antidepressant effects and the associated brain functional alterations in patients with propofol-ECT-resistant depression.

Psychiatry Research March 6, 2020 Jianjing Zhang, H. Tian, Jie Li et al. 13 citations

New methods for using ketamine in patients with propofol-electroconvulsive therapy-resistant depression (ECT-RD) are needed in the clinic. This study aimed to investigate the therapeutic efficacy of ketamine plus ECT in ECT-RD patients, along with the treatment-induced brain alterations. A total of 28 ECT-RD patients were intravenously injected with ketamine six times and treated with...

DOI: 10.1016/j.psychres.2020.112907 (opens in new tab) Full text (opens in new tab)