Neuroimage
May 15, 2009
Catie Chang, Gary H. Glover
510 citations
Previous studies have reported that the spontaneous, resting-state time course of the default-mode network is negatively correlated with that of the "task-positive network", a collection of regions commonly recruited in demanding cognitive tasks. However, all studies of negative correlations between the default-mode and task-positive networks have employed some form of normalization or...
Human Brain Mapping
February 10, 2009
Alexandre R. Franco, Aaron Pritchard, Vince D Calhoun et al.
129 citations
There has been a growing interest in the neuroimaging community regarding resting state data (i.e., passive mental activity) and the subsequent activation of the so-called default mode network (DMN). Although this network was originally characterized by a pattern of deactivation during active cognitive states, more recent applications of data-driven techniques such as independent component...
Neuroimage
January 15, 2009
K. Jann, T. Dierks, C. Boesch et al.
290 citations
Phase locking or synchronization of brain areas is a key concept of information processing in the brain. Synchronous oscillations have been observed and investigated extensively in EEG during the past decades. EEG oscillations occur over a wide frequency range. In EEG, a prominent type of oscillations is alpha-band activity, present typically when a subject is awake, but at rest with closed...
Psychological Medicine
August 1, 2008
Edith Pomarol‐Clotet, R. Salvador, Salvador Sarró et al.
Background: Functional imaging studies using working memory tasks have documented both prefrontal cortex (PFC) hypo- and hyperactivation in schizophrenia. However, these studies have often failed to consider the potential role of task-related deactivation. Method: Thirty-two patients with chronic schizophrenia and 32 age- and sex-matched normal controls underwent functional magnetic resonance...
Neurobiology of Aging
August 1, 2008
Fabio Sambataro, Vishnu P. Murty, Joseph H. Callicott et al.
534 citations
The default mode network (DMN) is a set of functionally connected brain regions which shows deactivation (task-induced deactivation, TID) during a cognitive task. Evidence shows an age-related decline in task-load-related modulation of the activity within the DMN during cognitive tasks. However, the effect of age on the functional coupling within the DMN and their relation to cognitive...
Neuroimage
June 13, 2008
Peter Fransson, Guillaume Marrelec
1,236 citations
Recent research has shown that intrinsic brain activity as observed by functional magnetic resonance imaging (fMRI) manifest itself as coherent signal changes in networks encompassing brain regions that span long-range neuronal pathways. One of these networks, the so called default mode network, has become the primary target in recent investigations to link intrinsic activity to cognition and...
Neuroreport
May 28, 2008
Robyn L. Bluhm, Elizabeth A. Osuch, Ruth A. Lanius et al.
229 citations
The 'default mode network' is a set of brain regions showing correlated, low-frequency activity during rest. It includes the posterior cingulate/precuneus, medial prefrontal cortex, and bilateral inferior parietal cortex. Earlier studies have characterized this network using either region of interest-based correlation analyses or data-driven techniques; however, there is some disagreement over...
Cerebral Cortex
April 9, 2008
Michael D. Greicius, Kaustubh Supekar, V. Menon et al.
2,227 citations
Resting-state functional connectivity magnetic resonance imaging (fcMRI) studies constitute a growing proportion of functional brain imaging publications. This approach detects temporal correlations in spontaneous blood oxygen level-dependent (BOLD) signal oscillations while subjects rest quietly in the scanner. Although distinct resting-state networks related to vision, language, executive...
Human Brain Mapping
January 24, 2008
Michael D. Greicius, Vesa Kiviniemi, Osmo Tervonen et al.
The default‐mode network (DMN) is a set of specific brain regions whose activity, predominant in the resting‐state, is attenuated during cognitively demanding, externally‐cued tasks. The cognitive correlates of this network have proven difficult to interrogate, but one hypothesis is that regions in the network process episodic memories and semantic knowledge integral to internally‐generated...
Human Brain Mapping
January 24, 2008
Lucina Q. Uddin, A.M. Clare Kelly, Bharat B. Biswal et al.
1,198 citations
The default mode network (DMN), based in ventromedial prefrontal cortex (vmPFC) and posterior cingulate cortex (PCC), exhibits higher metabolic activity at rest than during performance of externally oriented cognitive tasks. Recent studies have suggested that competitive relationships between the DMN and various task-positive networks involved in task performance are intrinsically represented...