Cerebral Cortex
August 1, 2017
Heidi Jiang, Matthew P White, Michael D. Greicius et al.
Hypnosis has proven clinical utility, yet changes in brain activity underlying the hypnotic state have not yet been fully identified. Previous research suggests that hypnosis is associated with decreased default mode network (DMN) activity and that high hypnotizability is associated with greater functional connectivity between the executive control network (ECN) and the salience network (SN)....
Cerebral Cortex
March 7, 2011
Elizabeth C. Mormino, Andre Smiljic, Amynta O. Hayenga et al.
349 citations
Although beta-amyloid (Aβ) deposition is a characteristic feature of Alzheimer's disease (AD), this pathology is commonly found in elderly normal controls (NC). The pattern of Aβ deposition as detected with Pittsburgh compound-B positron emission tomography (PIB-PET) imaging shows substantial spatial overlap with the default mode network (DMN), a group of brain regions that typically...
Proceedings of the National Academy of Sciences
February 15, 2011
Mohammad Dastjerdi, Brett L Foster, Sharmin Nasrullah et al.
The electrophysiological basis for higher brain activity during rest and internally directed cognition within the human default mode network (DMN) remains largely unknown. Here we use intracranial recordings in the human posteromedial cortex (PMC), a core node within the DMN, during conditions of cued rest, autobiographical judgments, and arithmetic processing. We found a heterogeneous profile...
Anesthesiology
September 30, 2010
Pierre Boveroux, Audrey Vanhaudenhuyse, Marie-Aurélie Bruno et al.
645 citations
BACKGROUND: Mechanisms of anesthesia-induced loss of consciousness remain poorly understood. Resting-state functional magnetic resonance imaging allows investigating whole-brain connectivity changes during pharmacological modulation of the level of consciousness. METHODS: Low-frequency spontaneous blood oxygen level-dependent fluctuations were measured in 19 healthy volunteers during...
Neuroimage
April 11, 2010
Kaustubh Supekar, Lucina Q. Uddin, Katherine E. Prater et al.
548 citations
Functional and structural maturation of networks comprised of discrete regions is an important aspect of brain development. The default-mode network (DMN) is a prominent network which includes the posterior cingulate cortex (PCC), medial prefrontal cortex (mPFC), medial temporal lobes (MTL), and angular gyrus (AG). Despite increasing interest in DMN function, little is known about its...
Cerebral Cortex
April 9, 2008
Michael D. Greicius, Kaustubh Supekar, V. Menon et al.
2,227 citations
Resting-state functional connectivity magnetic resonance imaging (fcMRI) studies constitute a growing proportion of functional brain imaging publications. This approach detects temporal correlations in spontaneous blood oxygen level-dependent (BOLD) signal oscillations while subjects rest quietly in the scanner. Although distinct resting-state networks related to vision, language, executive...
Human Brain Mapping
January 24, 2008
Michael D. Greicius, Vesa Kiviniemi, Osmo Tervonen et al.
The default‐mode network (DMN) is a set of specific brain regions whose activity, predominant in the resting‐state, is attenuated during cognitively demanding, externally‐cued tasks. The cognitive correlates of this network have proven difficult to interrogate, but one hypothesis is that regions in the network process episodic memories and semantic knowledge integral to internally‐generated...
Proceedings of the National Academy of Sciences
December 27, 2002
Michael D. Greicius, B. Krasnow, Allan L. Reiss et al.
Functional imaging studies have shown that certain brain regions, including posterior cingulate cortex (PCC) and ventral anterior cingulate cortex (vACC), consistently show greater activity during resting states than during cognitive tasks. This finding led to the hypothesis that these regions constitute a network supporting a default mode of brain function. In this study, we investigate three...