Default mode network connectivity: effects of age, sex, and analytic approach
Robyn L. Bluhm, Elizabeth A. Osuch, Ruth A. Lanius, Kristine Boksman, Richard W.J. Neufeld, Jean Théberge, Peter Williamson
Neuroreport May 28, 2008 DOI: 10.1097/wnr.0b013e328300ebbf (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Sample size | 40 |
| Population | Human participants |
| Topics | Default mode network |
| Citations | 229 |
| Key findings | Both region of interest-based correlation analyses and independent component analysis identify the default mode network, but show less agreement on age and sex differences. |
Abstract
The 'default mode network' is a set of brain regions showing correlated, low-frequency activity during rest. It includes the posterior cingulate/precuneus, medial prefrontal cortex, and bilateral inferior parietal cortex. Earlier studies have characterized this network using either region of interest-based correlation analyses or data-driven techniques; however, there is some disagreement over which method is superior. We conducted both types of analysis on a large (N=40) data set and also investigated age and sex differences in the network. Both region of interest-based analyses and independent component analysis identified the default mode network. Age and sex differences were small and there was less agreement between analytic techniques regarding age and sex effects than regarding default mode network structure.
Comparable studies
Other observational and cohort studies on default mode network, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| A default mode of brain function Normal adult human brain | 2001 | Observational study | |
| Resting-State Functional Connectivity Reflects Structural Connectivity in the Default Mode Network Healthy subjects | 2008 | Observational cohort | |
| Meditation experience is associated with increased cortical thickness Participants with extensive Insight meditation experience and matched controls | 2005 | Observational cohort | n = 20 |
| Meditation experience is associated with differences in default mode network activity and connectivity Experienced meditators and matched meditation-naive controls | 2011 | Observational cohort | |
| The precuneus/posterior cingulate cortex plays a pivotal role in the default mode network: Evidence from a partial correlation network analysis Healthy subjects | 2008 | Observational study |
Citations in the library
Cited by 9
- The Default Mode Network in Healthy Individuals: A Systematic Review and Meta-Analysis Brain Connectivity December 5, 2016
- Fréquence et contenu du rapport de rêve : approches comportementales et neurophysiologiques HAL (Le Centre pour la Communication Scientifique Directe) December 8, 2017
- Functional Importance Backbones of the Brain at Rest, Wakefulness, and Sleep. Brain Sciences July 20, 2025
- Resting state functional connectivity in the default mode network: Relationships between cannabis use, gender, and cognition in adolescents and young adults NeuroImage: Clinical April 8, 2021
- Default mode network connectivity is related to pain frequency and intensity in adolescents NeuroImage: Clinical June 25, 2020
and 4 more in the library