Journal of Affective Disorders
July 15, 2026
Iman Kiani, Giulia Cattarinussi, Fabio Sambataro et al.
Major depressive disorder (MDD) is a leading cause of disability worldwide, with a significant portion of patients experiencing treatment-resistant depression (TRD). Ketamine, a rapid-acting antidepressant, has shown promise in alleviating symptoms of TRD and suicidality, but variability in treatment response remains a challenge. Identifying neuroimaging biomarkers that predict responsiveness...
Journal of Affective Disorders
February 1, 2025
Farzaneh Ramezani, Peyman Mardani, Fatemeh Nemati et al.
4 citations
Over the last two decades, ketamine has gained significant interest in psychiatry as a potential treatment for major depressive disorder (MDD), especially in individuals who are resistant to traditional therapies or are at a high risk of suicide. Task-based functional magnetic resonance imaging (fMRI) studies can provide insight into how ketamine alters brain function and contributes to its...
Addiction Biology
November 22, 2021
Dusan Hirjak, Mike M. Schmitgen, Florian Werler et al.
33 citations
Heavy cannabis use (HCU) is frequently associated with a plethora of cognitive, psychopathological and sensorimotor phenomena. Although HCU is frequent, specific patterns of abnormal brain structure and function underlying HCU in individuals presenting without cannabis-use disorder or other current and life-time major mental disorders are unclear at present. This multimodal magnetic resonance...
European Neuropsychopharmacology
May 1, 2019
Reham Fahmy, Maha Wasfi, Rania Mamdouh et al.
Recently, mindfulness-based programs have shown promising clinical effects in the treatment of substance-use disorders (SUD). While several studies linked mindfulness to decreased default mode network (DMN) connectivity in meditators, only a few studies investigated its effects in patients with SUD. This study aimed to detect changes in DMN connectivity in opiate dependent patients receiving...
Journal of Psychiatry and Neuroscience
October 20, 2011
Nadine Donata Wolf, Fabio Sambataro, Nenad Vasić et al.
138 citations
BACKGROUND: Functional neuroimaging studies on schizophrenia have suggested abnormal task-related functional connectivity in patients with schizophrenia who have auditory verbal hallucinations (AVHs). However, little is known about intrinsic functional connectivity in these patients. METHODS: Between January 2009 and February 2010, we studied patients with schizophrenia who had persistent and...
Schizophrenia Bulletin
October 5, 2011
Fabio Sambataro, Leonardo Fazio, Paolo Taurisano et al.
59 citations
The default mode network (DMN) comprises a set of brain regions with "increased" activity during rest relative to cognitive processing. Activity in the DMN is associated with functional connections with the striatum and dopamine (DA) levels in this brain region. A functional single-nucleotide polymorphism within the dopamine D2 receptor gene (DRD2, rs1076560 G > T) shifts splicing of the 2 D2...
Neuropsychopharmacology
June 1, 2010
Giacomo Salvadore, Brian R Cornwell, Fabio Sambataro et al.
Pregenual anterior cingulate cortex (pgACC) hyperactivity differentiates treatment responders from non-responders to various pharmacological antidepressant interventions, including ketamine, an N -methyl- D -aspartate receptor antagonist. Evidence of pgACC hyperactivition during non-emotional working memory tasks in patients with major depressive disorder (MDD) highlights the importance of this...
Neurobiology of Aging
August 1, 2008
Fabio Sambataro, Vishnu P. Murty, Joseph H. Callicott et al.
534 citations
The default mode network (DMN) is a set of functionally connected brain regions which shows deactivation (task-induced deactivation, TID) during a cognitive task. Evidence shows an age-related decline in task-load-related modulation of the activity within the DMN during cognitive tasks. However, the effect of age on the functional coupling within the DMN and their relation to cognitive...