Biological Psychiatry
2019
Kaustubh Supekar, Weidong Cai, R. Krishnadas et al.
BACKGROUND Schizophrenia is a highly disabling psychiatric disorder characterized by a range of positive "psychosis" symptoms. However, the neurobiology of psychosis and associated systems-level disruptions in the brain remain poorly understood. Here, we test an aberrant saliency model of psychosis, which posits that dysregulated dynamic cross-network interactions among the salience network...
Cerebral Cortex
April 9, 2008
Michael D. Greicius, Kaustubh Supekar, V. Menon et al.
2,227 citations
Resting-state functional connectivity magnetic resonance imaging (fcMRI) studies constitute a growing proportion of functional brain imaging publications. This approach detects temporal correlations in spontaneous blood oxygen level-dependent (BOLD) signal oscillations while subjects rest quietly in the scanner. Although distinct resting-state networks related to vision, language, executive...
Human Brain Mapping
January 24, 2008
Michael D. Greicius, Vesa Kiviniemi, Osmo Tervonen et al.
The default‐mode network (DMN) is a set of specific brain regions whose activity, predominant in the resting‐state, is attenuated during cognitively demanding, externally‐cued tasks. The cognitive correlates of this network have proven difficult to interrogate, but one hypothesis is that regions in the network process episodic memories and semantic knowledge integral to internally‐generated...
Proceedings of the National Academy of Sciences
December 27, 2002
Michael D. Greicius, B. Krasnow, Allan L. Reiss et al.
Functional imaging studies have shown that certain brain regions, including posterior cingulate cortex (PCC) and ventral anterior cingulate cortex (vACC), consistently show greater activity during resting states than during cognitive tasks. This finding led to the hypothesis that these regions constitute a network supporting a default mode of brain function. In this study, we investigate three...