Altered Coactive Micropattern Connectivity in the Default-Mode Network during the Sleep-Wake Cycle
Yan Cui, Qiao Chen, Yang Xia, Zeru Wang, Yujia Guo, Ge Zhang, Dezhong Yao, Daqing Guo
Neural Plasticity November 23, 2020 DOI: 10.1155/2020/8876131 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Population | Rats |
| Topics | Default mode network |
| Key findings | Three coactive micropattern networks within the rat default-mode network show greater functional connectivity and efficiency than the original DMN structure, and their characteristics differ between waking and sleep states. |
Abstract
The default-mode network (DMN) is believed to be associated with levels of consciousness, but how the functional connectivity (FC) of the DMN changes across different states of consciousness is still unclear. In the current work, we addressed this issue by exploring the coactive micropattern (CAMP) networks of the DMN according to the CAMPs of rat DMN activity during the sleep-wake cycle and tracking their topological alterations among different states of consciousness. Three CAMP networks were observed in DMN activity, and they displayed greater FC and higher efficiency than the original DMN structure in all states of consciousness, implying more efficient information processing in the CAMP networks. Furthermore, no significant differences in FC or network properties were found among the three CAMP networks in the waking state. However, the three networks were distinct in their characteristics in two sleep states, indicating that different CAMP networks played specific roles in distinct sleep states. In addition, we found that the changes in the FC and network properties of the CAMP networks were similar to those in the original DMN structure, suggesting intrinsic effects of various states of consciousness on DMN dynamics. Our findings revealed three underlying CAMP networks within the DMN dynamics and deepened the current knowledge concerning FC alterations in the DMN during conscious changes in the sleep-wake cycle.
Comparable studies
Other preclinical and animal studies on default mode network, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Rat brains also have a default mode network Rats | 2012 | Observational study | |
| Large-scale topology and the default mode network in the mouse connectome Mouse brain | 2014 | Observational study | |
| Hippocampal Sharp-Wave Ripples Influence Selective Activation of the Default Mode Network Anesthetized monkeys | 2016 | Observational study | |
| Psilocybin-induced default mode network hypoconnectivity is blunted in alcohol-dependent rats Healthy rats and a rat model of alcohol relapse | 2023 | Randomized, placebo-controlled crossover pharmaco-fMRI study | |
| Altered functional connectivity within the default mode network in two animal models with opposing episodic memories Rats (control, LPS-challenged, and footshock-exposed groups) | 2018 | Animal model study |
Citations in the library
Cites 14
- A default mode of brain function Proceedings of the National Academy of Sciences January 16, 2001
- The Brain's Default Mode Network Annual Review of Neuroscience May 4, 2015
- Decoupling of the brain's default mode network during deep sleep Proceedings of the National Academy of Sciences June 19, 2009
- Rat brains also have a default mode network Proceedings of the National Academy of Sciences February 21, 2012
- Development of the Brain's Default Mode Network from Wakefulness to Slow Wave Sleep Cerebral Cortex February 17, 2011
and 9 more in the library