Resting-State Functional EEG Connectivity in Salience and Default Mode Networks and their Relationship to Dissociative Symptoms During NMDA Receptor Antagonism.
Sara de la Salle, Joëlle Choueiry, D. Shah, Hayley Bowers, J. McIntosh, Vadim Ilivitsky, Brooke Carroll, V. Knott
Pharmacology, Biochemistry, and Behavior December 29, 2020 DOI: 10.1016/j.pbb.2020.173092 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Sample size | 21 |
| Population | Healthy volunteers |
| Intervention | Ketamine |
| Dose | subanesthetic dose |
| Topics | Default mode network |
| Key findings | Ketamine produced dissociation symptoms and frequency-dependent increases and decreases in EEG connectivity within and between the default mode and salience networks. The authors argue these altered network couplings and emergent dissociative symptoms tentatively support an NMDAR-hypofunction hypothesis of disturbed electrophysiologic connectivity in schizophrenia. |
Abstract
N-methyl-D-aspartate receptor (NMDAR) antagonists administered to healthy humans results in schizophrenia-like symptoms, which are thought in part to be related to glutamatergically altered electrophysiological connectivity in large-scale intrinsic functional brain networks. Here, we examine resting-state source electroencephalographic (EEG) connectivity within and between the default mode (DMN: for self-related cognitive activity) and salience networks (SN: for detection of salient stimuli in internal and external environments) in 21 healthy volunteers administered a subanesthetic dose of the dissociative anesthetic and NMDAR antagonist, ketamine. In addition to provoking symptoms of dissociation, which are thought to originate from an altered sense of self that is common to schizophrenia, ketamine induces frequency-dependent increases and decreases in connectivity within and between DMN and SN. These altered interactive network couplings together with emergent dissociative symptoms tentatively support an NMDAR-hypofunction hypothesis of disturbed electrophysiologic connectivity in schizophrenia.
Comparable studies
Other experimental studies on default mode network, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Functional connectivity of default mode network components: Correlation, anticorrelation, and causality Healthy subjects | 2008 | Observational study using resting-state fMRI and seed correlation analysis | |
| Patterns of Brain Activity Supporting Autobiographical Memory, Prospection, and Theory of Mind, and Their Relationship to the Default Mode Network Healthy subjects | 2009 | Experimental study using fMRI | |
| Dynamic reconfiguration of the default mode network during narrative comprehension Human subjects | 2016 | Experimental study | |
| Broadband Cortical Desynchronization Underlies the Human Psychedelic State Healthy human participants | 2013 | Experimental study | |
| The brain on art: intense aesthetic experience activates the default mode network Human observers | 2012 | Observational study with fMRI and behavioral analysis |
Citations in the library
Cited by 4
- Opposite Modulation of the NMDA Receptor by Glycine and S-Ketamine and the Effects on Resting State EEG Gamma Activity: New Insights into the Glutamate Hypothesis of Schizophrenia International Journal of Molecular Sciences January 18, 2023
- A circuit dissection of perception-action decoupling in S-ketamine-induced hallucination-like states. Molecular Psychiatry September 19, 2026
- Ketamine induces EEG oscillations that may aid anesthetic state but not dissociation monitoring Clinical Neurophysiology October 1, 2021
- Ketamine Alters Functional Gamma and Theta Resting-State Connectivity in Healthy Humans: Implications for Schizophrenia Treatment Targeting the Glutamate System. Frontiers in Psychiatry 2021
Cites 26
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- Evidence that Subanesthetic Doses of Ketamine Cause Sustained Disruptions of NMDA and AMPA-Mediated Frontoparietal Connectivity in Humans Journal of Neuroscience August 19, 2015
- Resting-state Network-specific Breakdown of Functional Connectivity during Ketamine Alteration of Consciousness in Volunteers Anesthesiology August 9, 2016
and 21 more in the library